The Hippo Signaling Pathway in Cardiac Development and Diseases

Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity. Thus, loss of cardiomyocytes from injury or diseases in ad...

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Autores principales: Mia, Masum M., Singh, Manvendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779857/
https://www.ncbi.nlm.nih.gov/pubmed/31632964
http://dx.doi.org/10.3389/fcell.2019.00211
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author Mia, Masum M.
Singh, Manvendra K.
author_facet Mia, Masum M.
Singh, Manvendra K.
author_sort Mia, Masum M.
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description Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity. Thus, loss of cardiomyocytes from injury or diseases in adults could lead to heart failure. The Hippo signaling pathway is a newly identified signaling cascade that modulates regenerative response by regulating cardiomyocyte proliferation in the embryonic heart, as well as in postnatal hearts after injury. In this review, we summarize recent findings highlighting the function and regulation of the Hippo signaling pathway in cardiac development and diseases.
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spelling pubmed-67798572019-10-18 The Hippo Signaling Pathway in Cardiac Development and Diseases Mia, Masum M. Singh, Manvendra K. Front Cell Dev Biol Cell and Developmental Biology Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity. Thus, loss of cardiomyocytes from injury or diseases in adults could lead to heart failure. The Hippo signaling pathway is a newly identified signaling cascade that modulates regenerative response by regulating cardiomyocyte proliferation in the embryonic heart, as well as in postnatal hearts after injury. In this review, we summarize recent findings highlighting the function and regulation of the Hippo signaling pathway in cardiac development and diseases. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6779857/ /pubmed/31632964 http://dx.doi.org/10.3389/fcell.2019.00211 Text en Copyright © 2019 Mia and Singh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Mia, Masum M.
Singh, Manvendra K.
The Hippo Signaling Pathway in Cardiac Development and Diseases
title The Hippo Signaling Pathway in Cardiac Development and Diseases
title_full The Hippo Signaling Pathway in Cardiac Development and Diseases
title_fullStr The Hippo Signaling Pathway in Cardiac Development and Diseases
title_full_unstemmed The Hippo Signaling Pathway in Cardiac Development and Diseases
title_short The Hippo Signaling Pathway in Cardiac Development and Diseases
title_sort hippo signaling pathway in cardiac development and diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779857/
https://www.ncbi.nlm.nih.gov/pubmed/31632964
http://dx.doi.org/10.3389/fcell.2019.00211
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