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ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma

PAI-1 plays significant roles in cancer occurrence, relapse and multidrug resistance and is highly expressed in tumours. ACT001, which is currently in phase I clinical trials for the treatment of glioblastoma (GBM). However, the detailed molecular mechanism of ACT001 is still unclear. In this study,...

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Detalles Bibliográficos
Autores principales:	Xi, Xiaonan, Liu, Ning, Wang, Qianqian, Chu, Yahui, Yin, Zheng, Ding, Yahui, Lu, Yaxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779874/ https://www.ncbi.nlm.nih.gov/pubmed/31591377 http://dx.doi.org/10.1038/s41419-019-1986-2

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