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ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12

Melanoma immunotherapy is still not satisfactory due to immunosuppressive cell populations within the tumor stroma. Targeting tumor-associated macrophages (TAM) can help to restore an anti-tumor immunity. Previously, we could show that classical TAM markers expressed in vivo need a 7 day M-CSF/dexam...

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Detalles Bibliográficos
Autores principales:	Kloss, Loreen, Dollt, Claudia, Schledzewski, Kai, Krewer, Andreas, Melchers, Susanne, Manta, Calin, Sticht, Carsten, Torre, Carolina de la, Utikal, Jochen, Umansky, Viktor, Schmieder, Astrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779894/ https://www.ncbi.nlm.nih.gov/pubmed/31591378 http://dx.doi.org/10.1038/s41419-019-2010-6

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