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Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila

It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cL...

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Autores principales: Zhao, Bohan, Sun, Jiameng, Zhang, Xuchen, Mo, Han, Niu, Yijun, Li, Qian, Wang, Lianzhang, Zhong, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779902/
https://www.ncbi.nlm.nih.gov/pubmed/31591396
http://dx.doi.org/10.1038/s41467-019-12436-7
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author Zhao, Bohan
Sun, Jiameng
Zhang, Xuchen
Mo, Han
Niu, Yijun
Li, Qian
Wang, Lianzhang
Zhong, Yi
author_facet Zhao, Bohan
Sun, Jiameng
Zhang, Xuchen
Mo, Han
Niu, Yijun
Li, Qian
Wang, Lianzhang
Zhong, Yi
author_sort Zhao, Bohan
collection PubMed
description It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cLTM). Single-trial conditioning yields cLTM that is formed immediately in a protein-synthesis independent manner and is sustained over 14 days without decay. Unlike retrieval of traditional LTM, which requires only the conditioned odour and is mediated by mushroom-body neurons, cLTM recall requires both the conditioned odour and reinstatement of the training-environmental context. It is mediated through lateral-horn neurons that connect to multiple sensory brain regions. The cLTM cannot be retrieved if synaptic transmission from any one of these centres is blocked, with effects similar to those of altered encoding context during retrieval. The present study provides strong evidence that long-term memory can be formed easily without the need for consolidation.
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spelling pubmed-67799022019-10-09 Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila Zhao, Bohan Sun, Jiameng Zhang, Xuchen Mo, Han Niu, Yijun Li, Qian Wang, Lianzhang Zhong, Yi Nat Commun Article It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cLTM). Single-trial conditioning yields cLTM that is formed immediately in a protein-synthesis independent manner and is sustained over 14 days without decay. Unlike retrieval of traditional LTM, which requires only the conditioned odour and is mediated by mushroom-body neurons, cLTM recall requires both the conditioned odour and reinstatement of the training-environmental context. It is mediated through lateral-horn neurons that connect to multiple sensory brain regions. The cLTM cannot be retrieved if synaptic transmission from any one of these centres is blocked, with effects similar to those of altered encoding context during retrieval. The present study provides strong evidence that long-term memory can be formed easily without the need for consolidation. Nature Publishing Group UK 2019-10-07 /pmc/articles/PMC6779902/ /pubmed/31591396 http://dx.doi.org/10.1038/s41467-019-12436-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhao, Bohan
Sun, Jiameng
Zhang, Xuchen
Mo, Han
Niu, Yijun
Li, Qian
Wang, Lianzhang
Zhong, Yi
Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila
title Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila
title_full Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila
title_fullStr Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila
title_full_unstemmed Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila
title_short Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila
title_sort long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779902/
https://www.ncbi.nlm.nih.gov/pubmed/31591396
http://dx.doi.org/10.1038/s41467-019-12436-7
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