A role for PKD1 in insulin secretion downstream of P2Y(1) receptor activation in mouse and human islets

Along with insulin, β‐cells co‐secrete the neurotransmitter ATP which acts as a positive autocrine signal via P2Y(1) receptors to activate phospholipase C and increase the production of diacylglycerol (DAG). However, the downstream signaling that couples P2Y(1) activation to insulin secretion remain...

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Detalles Bibliográficos
Autores principales: Khan, Shara, Ferdaoussi, Mourad, Bautista, Austin, Bergeron, Valérie, Smith, Nancy, Poitout, Vincent, MacDonald, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779929/
https://www.ncbi.nlm.nih.gov/pubmed/31591827
http://dx.doi.org/10.14814/phy2.14250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779929/
https://www.ncbi.nlm.nih.gov/pubmed/31591827
http://dx.doi.org/10.14814/phy2.14250

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