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Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study
BACKGROUND: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chin...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779932/ https://www.ncbi.nlm.nih.gov/pubmed/31730677 http://dx.doi.org/10.5045/br.2019.54.3.175 |
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author | Huang, Duo Wong, Emmanuel Zuo, Ming-Liang Chan, Pak-Hei Yue, Wen-Sheng Hu, Hou-Xiang Chen, Ling Yin, Li-Xue Cui, Xin-Wu Wu, Ming-Xiang Su, Xi Siu, Chung-Wah Hai, Jo-Jo |
author_facet | Huang, Duo Wong, Emmanuel Zuo, Ming-Liang Chan, Pak-Hei Yue, Wen-Sheng Hu, Hou-Xiang Chen, Ling Yin, Li-Xue Cui, Xin-Wu Wu, Ming-Xiang Su, Xi Siu, Chung-Wah Hai, Jo-Jo |
author_sort | Huang, Duo |
collection | PubMed |
description | BACKGROUND: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism. METHODS: In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed. RESULTS: The mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29–36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pulmonary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester. CONCLUSION: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. |
format | Online Article Text |
id | pubmed-6779932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis |
record_format | MEDLINE/PubMed |
spelling | pubmed-67799322019-10-16 Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study Huang, Duo Wong, Emmanuel Zuo, Ming-Liang Chan, Pak-Hei Yue, Wen-Sheng Hu, Hou-Xiang Chen, Ling Yin, Li-Xue Cui, Xin-Wu Wu, Ming-Xiang Su, Xi Siu, Chung-Wah Hai, Jo-Jo Blood Res Original Article BACKGROUND: Previous Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum period in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism. METHODS: In this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed. RESULTS: The mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29–36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pulmonary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester. CONCLUSION: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2019-09 2019-09-25 /pmc/articles/PMC6779932/ /pubmed/31730677 http://dx.doi.org/10.5045/br.2019.54.3.175 Text en © 2019 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Huang, Duo Wong, Emmanuel Zuo, Ming-Liang Chan, Pak-Hei Yue, Wen-Sheng Hu, Hou-Xiang Chen, Ling Yin, Li-Xue Cui, Xin-Wu Wu, Ming-Xiang Su, Xi Siu, Chung-Wah Hai, Jo-Jo Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study |
title | Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study |
title_full | Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study |
title_fullStr | Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study |
title_full_unstemmed | Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study |
title_short | Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study |
title_sort | risk of venous thromboembolism in chinese pregnant women: hong kong venous thromboembolism study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779932/ https://www.ncbi.nlm.nih.gov/pubmed/31730677 http://dx.doi.org/10.5045/br.2019.54.3.175 |
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