Potential role of Lu/BCAM in HIV-related atherosclerosis

Atheromatous lesions are formed by macrophages and low-density lipoprotein cholesterol invading the vascular intima. Here we show that increasing cholesterol levels are associated with peripheral monocyte depletion and this imbalance is aggravated by carriage of Lu/BCAM leukocyte adhesion molecules....

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Detalles Bibliográficos
Autores principales: Motswaledi, Modisa S., Kasvosve, Ishmael, Oguntibeju, Oluwafemi O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779996/
https://www.ncbi.nlm.nih.gov/pubmed/31616617
http://dx.doi.org/10.4102/ajlm.v8i1.792
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author Motswaledi, Modisa S.
Kasvosve, Ishmael
Oguntibeju, Oluwafemi O.
author_facet Motswaledi, Modisa S.
Kasvosve, Ishmael
Oguntibeju, Oluwafemi O.
author_sort Motswaledi, Modisa S.
collection PubMed
description Atheromatous lesions are formed by macrophages and low-density lipoprotein cholesterol invading the vascular intima. Here we show that increasing cholesterol levels are associated with peripheral monocyte depletion and this imbalance is aggravated by carriage of Lu/BCAM leukocyte adhesion molecules. This is true only in HIV infection and probably explains the risk of atherosclerosis observed in HIV-positive patients.
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spelling pubmed-67799962019-10-15 Potential role of Lu/BCAM in HIV-related atherosclerosis Motswaledi, Modisa S. Kasvosve, Ishmael Oguntibeju, Oluwafemi O. Afr J Lab Med Brief Report Atheromatous lesions are formed by macrophages and low-density lipoprotein cholesterol invading the vascular intima. Here we show that increasing cholesterol levels are associated with peripheral monocyte depletion and this imbalance is aggravated by carriage of Lu/BCAM leukocyte adhesion molecules. This is true only in HIV infection and probably explains the risk of atherosclerosis observed in HIV-positive patients. AOSIS 2019-09-30 /pmc/articles/PMC6779996/ /pubmed/31616617 http://dx.doi.org/10.4102/ajlm.v8i1.792 Text en © 2019. The Authors https://creativecommons.org/licenses/by/4.0/ Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.
spellingShingle Brief Report
Motswaledi, Modisa S.
Kasvosve, Ishmael
Oguntibeju, Oluwafemi O.
Potential role of Lu/BCAM in HIV-related atherosclerosis
title Potential role of Lu/BCAM in HIV-related atherosclerosis
title_full Potential role of Lu/BCAM in HIV-related atherosclerosis
title_fullStr Potential role of Lu/BCAM in HIV-related atherosclerosis
title_full_unstemmed Potential role of Lu/BCAM in HIV-related atherosclerosis
title_short Potential role of Lu/BCAM in HIV-related atherosclerosis
title_sort potential role of lu/bcam in hiv-related atherosclerosis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779996/
https://www.ncbi.nlm.nih.gov/pubmed/31616617
http://dx.doi.org/10.4102/ajlm.v8i1.792
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AT kasvosveishmael potentialroleoflubcaminhivrelatedatherosclerosis
AT oguntibejuoluwafemio potentialroleoflubcaminhivrelatedatherosclerosis

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