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Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface

Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection. Long term pathology persists well beyond the resolution of viral replic...

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Autores principales: Pennington, Matthew R., Saha, Amrita, Painter, David F., Gavazzi, Christina, Ismail, Ashrafali M., Zhou, Xiaohong, Chodosh, James, Rajaiya, Jaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780103/
https://www.ncbi.nlm.nih.gov/pubmed/31540200
http://dx.doi.org/10.3390/microorganisms7090351
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author Pennington, Matthew R.
Saha, Amrita
Painter, David F.
Gavazzi, Christina
Ismail, Ashrafali M.
Zhou, Xiaohong
Chodosh, James
Rajaiya, Jaya
author_facet Pennington, Matthew R.
Saha, Amrita
Painter, David F.
Gavazzi, Christina
Ismail, Ashrafali M.
Zhou, Xiaohong
Chodosh, James
Rajaiya, Jaya
author_sort Pennington, Matthew R.
collection PubMed
description Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection. Long term pathology persists well beyond the resolution of viral replication, indicating that the prolonged immune response is not virus-mediated. However, it is not clear how these responses are sustained or even initiated following infection. This review discusses recent work from our laboratory and others which demonstrates different entry pathways specific to both adenovirus and cell type. These findings suggest that adenoviruses may stimulate specific pattern recognition receptors in an entry/trafficking-dependent manner, leading to distinct immune responses dependent on the virus/cell type combination. Additional work is needed to understand the specific connections between adenoviral entry and the stimulation of innate immune responses by the various cell types present on the ocular surface.
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spelling pubmed-67801032019-10-30 Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface Pennington, Matthew R. Saha, Amrita Painter, David F. Gavazzi, Christina Ismail, Ashrafali M. Zhou, Xiaohong Chodosh, James Rajaiya, Jaya Microorganisms Review Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection. Long term pathology persists well beyond the resolution of viral replication, indicating that the prolonged immune response is not virus-mediated. However, it is not clear how these responses are sustained or even initiated following infection. This review discusses recent work from our laboratory and others which demonstrates different entry pathways specific to both adenovirus and cell type. These findings suggest that adenoviruses may stimulate specific pattern recognition receptors in an entry/trafficking-dependent manner, leading to distinct immune responses dependent on the virus/cell type combination. Additional work is needed to understand the specific connections between adenoviral entry and the stimulation of innate immune responses by the various cell types present on the ocular surface. MDPI 2019-09-13 /pmc/articles/PMC6780103/ /pubmed/31540200 http://dx.doi.org/10.3390/microorganisms7090351 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pennington, Matthew R.
Saha, Amrita
Painter, David F.
Gavazzi, Christina
Ismail, Ashrafali M.
Zhou, Xiaohong
Chodosh, James
Rajaiya, Jaya
Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
title Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
title_full Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
title_fullStr Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
title_full_unstemmed Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
title_short Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
title_sort disparate entry of adenoviruses dictates differential innate immune responses on the ocular surface
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780103/
https://www.ncbi.nlm.nih.gov/pubmed/31540200
http://dx.doi.org/10.3390/microorganisms7090351
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