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Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children
Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (n = 2929 participants), measuring 158 metabolic traits in non-fasting EDTA-plasma by nuclear magnetic resonance. We as...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780115/ https://www.ncbi.nlm.nih.gov/pubmed/31546923 http://dx.doi.org/10.3390/metabo9090191 |
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author | Santos Ferreira, Diana L. Hübel, Christopher Herle, Moritz Abdulkadir, Mohamed Loos, Ruth J. F. Bryant-Waugh, Rachel Bulik, Cynthia M. De Stavola, Bianca L. Lawlor, Deborah A. Micali, Nadia |
author_facet | Santos Ferreira, Diana L. Hübel, Christopher Herle, Moritz Abdulkadir, Mohamed Loos, Ruth J. F. Bryant-Waugh, Rachel Bulik, Cynthia M. De Stavola, Bianca L. Lawlor, Deborah A. Micali, Nadia |
author_sort | Santos Ferreira, Diana L. |
collection | PubMed |
description | Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (n = 2929 participants), measuring 158 metabolic traits in non-fasting EDTA-plasma by nuclear magnetic resonance. We associated metabolic markers at 7 years (exposure) with risk for anorexia nervosa and binge-eating disorder (outcomes) at 14, 16, and 18 years using logistic regression adjusted for maternal education, child’s sex, age, body mass index, and calorie intake at 7 years. Elevated very low-density lipoproteins, triglycerides, apolipoprotein-B/A, and monounsaturated fatty acids ratio were associated with lower odds of anorexia nervosa at age 18, while elevated high-density lipoproteins, docosahexaenoic acid and polyunsaturated fatty acids ratio, and fatty acid unsaturation were associated with higher risk for anorexia nervosa at 18 years. Elevated linoleic acid and n-6 fatty acid ratios were associated with lower odds of binge-eating disorder at 16 years, while elevated saturated fatty acid ratio was associated with higher odds of binge-eating disorder. Most associations had large confidence intervals and showed, for anorexia nervosa, different directions across time points. Overall, our results show some evidence for a role of metabolic factors in eating disorders development in adolescence. |
format | Online Article Text |
id | pubmed-6780115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67801152019-10-30 Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children Santos Ferreira, Diana L. Hübel, Christopher Herle, Moritz Abdulkadir, Mohamed Loos, Ruth J. F. Bryant-Waugh, Rachel Bulik, Cynthia M. De Stavola, Bianca L. Lawlor, Deborah A. Micali, Nadia Metabolites Article Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (n = 2929 participants), measuring 158 metabolic traits in non-fasting EDTA-plasma by nuclear magnetic resonance. We associated metabolic markers at 7 years (exposure) with risk for anorexia nervosa and binge-eating disorder (outcomes) at 14, 16, and 18 years using logistic regression adjusted for maternal education, child’s sex, age, body mass index, and calorie intake at 7 years. Elevated very low-density lipoproteins, triglycerides, apolipoprotein-B/A, and monounsaturated fatty acids ratio were associated with lower odds of anorexia nervosa at age 18, while elevated high-density lipoproteins, docosahexaenoic acid and polyunsaturated fatty acids ratio, and fatty acid unsaturation were associated with higher risk for anorexia nervosa at 18 years. Elevated linoleic acid and n-6 fatty acid ratios were associated with lower odds of binge-eating disorder at 16 years, while elevated saturated fatty acid ratio was associated with higher odds of binge-eating disorder. Most associations had large confidence intervals and showed, for anorexia nervosa, different directions across time points. Overall, our results show some evidence for a role of metabolic factors in eating disorders development in adolescence. MDPI 2019-09-19 /pmc/articles/PMC6780115/ /pubmed/31546923 http://dx.doi.org/10.3390/metabo9090191 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Santos Ferreira, Diana L. Hübel, Christopher Herle, Moritz Abdulkadir, Mohamed Loos, Ruth J. F. Bryant-Waugh, Rachel Bulik, Cynthia M. De Stavola, Bianca L. Lawlor, Deborah A. Micali, Nadia Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children |
title | Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children |
title_full | Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children |
title_fullStr | Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children |
title_full_unstemmed | Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children |
title_short | Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children |
title_sort | associations between blood metabolic profile at 7 years old and eating disorders in adolescence: findings from the avon longitudinal study of parents and children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780115/ https://www.ncbi.nlm.nih.gov/pubmed/31546923 http://dx.doi.org/10.3390/metabo9090191 |
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