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The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan

Background: The pool of brain-dead donors (BDDs) was increased with the revision to the relevant law in 2010, and islet transplantation from BDDs was started in 2013. The present study assessed the influence of using pancreases from BDDs on islet transplantation in Japan. Methods: The donor informat...

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Autores principales: Ito, Taihei, Kenmochi, Takashi, Kurihara, Kei, Kawai, Akihiro, Aida, Naohiro, Akashi, Yumi, Kato, Sakurako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780198/
https://www.ncbi.nlm.nih.gov/pubmed/31510059
http://dx.doi.org/10.3390/jcm8091430
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author Ito, Taihei
Kenmochi, Takashi
Kurihara, Kei
Kawai, Akihiro
Aida, Naohiro
Akashi, Yumi
Kato, Sakurako
author_facet Ito, Taihei
Kenmochi, Takashi
Kurihara, Kei
Kawai, Akihiro
Aida, Naohiro
Akashi, Yumi
Kato, Sakurako
author_sort Ito, Taihei
collection PubMed
description Background: The pool of brain-dead donors (BDDs) was increased with the revision to the relevant law in 2010, and islet transplantation from BDDs was started in 2013. The present study assessed the influence of using pancreases from BDDs on islet transplantation in Japan. Methods: The donor information registered with the secretariat of islet transplants from 2012 was reviewed, and the results of 86 clinical islet isolations performed in Japan between 2003 and 2018 with non-heart-beating donors (NHBDs) (n = 71) and BDDs (n = 15) were investigated. Results: The number of cases for which donor information was registered with the secretariat of islet transplants increased to 1.84 cases/month from 2013 to 2018 in comparison to 1.44/month in 2012, when only NHBDs were used. The median pancreatic islet yield was 275,550 IEQ (Islet equivalents) in the NHBD group but 362,700 in the BDD group, which amounted to a statistically significant difference (p = 0.02). As a result, 38/71 cases (53.5%) were achieved successful islet isolation (>5000 IEQ per recipient weight (kg)) was achieved in 38/71 cases (53.5%) in the NHBD group, and 12/15 cases (80.0%) in the BDD group; thus, the rate of successful islet transplantation was higher in the BDD group. Conclusion: The use of pancreases from BDDs has increased the overall number of cases for which donor information is registered with the secretariat of islet transplants and has improved the performance of islet isolation, thereby increasing the probability of successfully achieving islet transplantation.
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spelling pubmed-67801982019-10-30 The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan Ito, Taihei Kenmochi, Takashi Kurihara, Kei Kawai, Akihiro Aida, Naohiro Akashi, Yumi Kato, Sakurako J Clin Med Article Background: The pool of brain-dead donors (BDDs) was increased with the revision to the relevant law in 2010, and islet transplantation from BDDs was started in 2013. The present study assessed the influence of using pancreases from BDDs on islet transplantation in Japan. Methods: The donor information registered with the secretariat of islet transplants from 2012 was reviewed, and the results of 86 clinical islet isolations performed in Japan between 2003 and 2018 with non-heart-beating donors (NHBDs) (n = 71) and BDDs (n = 15) were investigated. Results: The number of cases for which donor information was registered with the secretariat of islet transplants increased to 1.84 cases/month from 2013 to 2018 in comparison to 1.44/month in 2012, when only NHBDs were used. The median pancreatic islet yield was 275,550 IEQ (Islet equivalents) in the NHBD group but 362,700 in the BDD group, which amounted to a statistically significant difference (p = 0.02). As a result, 38/71 cases (53.5%) were achieved successful islet isolation (>5000 IEQ per recipient weight (kg)) was achieved in 38/71 cases (53.5%) in the NHBD group, and 12/15 cases (80.0%) in the BDD group; thus, the rate of successful islet transplantation was higher in the BDD group. Conclusion: The use of pancreases from BDDs has increased the overall number of cases for which donor information is registered with the secretariat of islet transplants and has improved the performance of islet isolation, thereby increasing the probability of successfully achieving islet transplantation. MDPI 2019-09-10 /pmc/articles/PMC6780198/ /pubmed/31510059 http://dx.doi.org/10.3390/jcm8091430 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ito, Taihei
Kenmochi, Takashi
Kurihara, Kei
Kawai, Akihiro
Aida, Naohiro
Akashi, Yumi
Kato, Sakurako
The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan
title The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan
title_full The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan
title_fullStr The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan
title_full_unstemmed The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan
title_short The Effects of Using Pancreases Obtained from Brain-Dead Donors for Clinical Islet Transplantation in Japan
title_sort effects of using pancreases obtained from brain-dead donors for clinical islet transplantation in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780198/
https://www.ncbi.nlm.nih.gov/pubmed/31510059
http://dx.doi.org/10.3390/jcm8091430
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