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The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging

Background: Syphilis, tuberculosis and toxoplasmosis are major infectious diseases worldwide; all of them are multisystem pathologies and share a possible ocular involvement. In this context, a fundamental help for the definitive diagnosis is provided by the ophthalmologist, through clinical evaluat...

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Autores principales: Pirani, Vittorio, Pelliccioni, Paolo, De Turris, Serena, Rosati, Alessandro, Franceschi, Alessandro, Cesari, Claudia, Nicolai, Michele, Mariotti, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780210/
https://www.ncbi.nlm.nih.gov/pubmed/31492008
http://dx.doi.org/10.3390/jcm8091392
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author Pirani, Vittorio
Pelliccioni, Paolo
De Turris, Serena
Rosati, Alessandro
Franceschi, Alessandro
Cesari, Claudia
Nicolai, Michele
Mariotti, Cesare
author_facet Pirani, Vittorio
Pelliccioni, Paolo
De Turris, Serena
Rosati, Alessandro
Franceschi, Alessandro
Cesari, Claudia
Nicolai, Michele
Mariotti, Cesare
author_sort Pirani, Vittorio
collection PubMed
description Background: Syphilis, tuberculosis and toxoplasmosis are major infectious diseases worldwide; all of them are multisystem pathologies and share a possible ocular involvement. In this context, a fundamental help for the definitive diagnosis is provided by the ophthalmologist, through clinical evaluation and with the aid of a multimodal imaging examination. Methods: We hereby describe selected cases who came to our attention and were visited in our eye clinic. In all clinics, the use of retinal and optic disc multimodal imaging during ophthalmological evaluation allowed to make a diagnosis of an infectious disease. Results: In our tertiary referral center more than 60 patients with syphilis, tuberculosis and toxoplasmosis have been evaluated in the last two years: In 60% of cases the ophthalmological evaluation was secondary to a previous diagnosis of an infectious disease, while in the remaining cases the ophthalmologist, with the help of a multimodal imaging examination and clinical evaluation, represented the physician who leads to the diagnosis. Conclusion: Our results confirm how in these life-threatening pathologies a prompt diagnosis is mandatory and may benefit from a multidisciplinary and multimodal imaging approach, especially during ophthalmological evaluation.
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spelling pubmed-67802102019-10-30 The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging Pirani, Vittorio Pelliccioni, Paolo De Turris, Serena Rosati, Alessandro Franceschi, Alessandro Cesari, Claudia Nicolai, Michele Mariotti, Cesare J Clin Med Article Background: Syphilis, tuberculosis and toxoplasmosis are major infectious diseases worldwide; all of them are multisystem pathologies and share a possible ocular involvement. In this context, a fundamental help for the definitive diagnosis is provided by the ophthalmologist, through clinical evaluation and with the aid of a multimodal imaging examination. Methods: We hereby describe selected cases who came to our attention and were visited in our eye clinic. In all clinics, the use of retinal and optic disc multimodal imaging during ophthalmological evaluation allowed to make a diagnosis of an infectious disease. Results: In our tertiary referral center more than 60 patients with syphilis, tuberculosis and toxoplasmosis have been evaluated in the last two years: In 60% of cases the ophthalmological evaluation was secondary to a previous diagnosis of an infectious disease, while in the remaining cases the ophthalmologist, with the help of a multimodal imaging examination and clinical evaluation, represented the physician who leads to the diagnosis. Conclusion: Our results confirm how in these life-threatening pathologies a prompt diagnosis is mandatory and may benefit from a multidisciplinary and multimodal imaging approach, especially during ophthalmological evaluation. MDPI 2019-09-05 /pmc/articles/PMC6780210/ /pubmed/31492008 http://dx.doi.org/10.3390/jcm8091392 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pirani, Vittorio
Pelliccioni, Paolo
De Turris, Serena
Rosati, Alessandro
Franceschi, Alessandro
Cesari, Claudia
Nicolai, Michele
Mariotti, Cesare
The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging
title The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging
title_full The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging
title_fullStr The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging
title_full_unstemmed The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging
title_short The Eye as a Window to Systemic Infectious Diseases: Old Enemies, New Imaging
title_sort eye as a window to systemic infectious diseases: old enemies, new imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780210/
https://www.ncbi.nlm.nih.gov/pubmed/31492008
http://dx.doi.org/10.3390/jcm8091392
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