Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes

In this work, cyclopropylamine (CPA) monomer was plasma-polymerized on poly (ε-caprolactone) nanofiber meshes using various deposition durations to obtain amine-rich surfaces in an effort to improve the cellular response of the meshes. Scanning electron microscopy and X-ray photoelectron spectroscop...

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Autores principales: Chan, Ke Vin, Asadian, Mahtab, Onyshchenko, Iuliia, Declercq, Heidi, Morent, Rino, De Geyter, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780329/
https://www.ncbi.nlm.nih.gov/pubmed/31466357
http://dx.doi.org/10.3390/nano9091215
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author Chan, Ke Vin
Asadian, Mahtab
Onyshchenko, Iuliia
Declercq, Heidi
Morent, Rino
De Geyter, Nathalie
author_facet Chan, Ke Vin
Asadian, Mahtab
Onyshchenko, Iuliia
Declercq, Heidi
Morent, Rino
De Geyter, Nathalie
author_sort Chan, Ke Vin
collection PubMed
description In this work, cyclopropylamine (CPA) monomer was plasma-polymerized on poly (ε-caprolactone) nanofiber meshes using various deposition durations to obtain amine-rich surfaces in an effort to improve the cellular response of the meshes. Scanning electron microscopy and X-ray photoelectron spectroscopy (XPS) were used to investigate the surface morphology and surface chemical composition of the PCL samples, respectively. The measured coating thickness was found to linearly increase with deposition duration at a deposition rate of 0.465 nm/s. XPS analysis revealed that plasma exposure time had a considerable effect on the surface N/C and O/C ratio as well as on amino grafting efficiency and amino selectivity. In addition, cell studies showed that cell adhesion and proliferation significantly improved for all coated samples.
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spelling pubmed-67803292019-10-30 Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes Chan, Ke Vin Asadian, Mahtab Onyshchenko, Iuliia Declercq, Heidi Morent, Rino De Geyter, Nathalie Nanomaterials (Basel) Article In this work, cyclopropylamine (CPA) monomer was plasma-polymerized on poly (ε-caprolactone) nanofiber meshes using various deposition durations to obtain amine-rich surfaces in an effort to improve the cellular response of the meshes. Scanning electron microscopy and X-ray photoelectron spectroscopy (XPS) were used to investigate the surface morphology and surface chemical composition of the PCL samples, respectively. The measured coating thickness was found to linearly increase with deposition duration at a deposition rate of 0.465 nm/s. XPS analysis revealed that plasma exposure time had a considerable effect on the surface N/C and O/C ratio as well as on amino grafting efficiency and amino selectivity. In addition, cell studies showed that cell adhesion and proliferation significantly improved for all coated samples. MDPI 2019-08-28 /pmc/articles/PMC6780329/ /pubmed/31466357 http://dx.doi.org/10.3390/nano9091215 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chan, Ke Vin
Asadian, Mahtab
Onyshchenko, Iuliia
Declercq, Heidi
Morent, Rino
De Geyter, Nathalie
Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes
title Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes
title_full Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes
title_fullStr Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes
title_full_unstemmed Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes
title_short Biocompatibility of Cyclopropylamine-Based Plasma Polymers Deposited at Sub-Atmospheric Pressure on Poly (ε-caprolactone) Nanofiber Meshes
title_sort biocompatibility of cyclopropylamine-based plasma polymers deposited at sub-atmospheric pressure on poly (ε-caprolactone) nanofiber meshes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780329/
https://www.ncbi.nlm.nih.gov/pubmed/31466357
http://dx.doi.org/10.3390/nano9091215
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