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Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography

Background: Retinitis Pigmentosa (RP) represents a retinal dystrophy with an extremely complex pathogenesis further worsened by the impairment of the retinal vascular supply. The main goal of this study was to identify different vascular patterns in RP, by means of optical coherence tomography angio...

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Autores principales: Arrigo, Alessandro, Romano, Francesco, Albertini, Giorgia, Aragona, Emanuela, Bandello, Francesco, Battaglia Parodi, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780333/
https://www.ncbi.nlm.nih.gov/pubmed/31510025
http://dx.doi.org/10.3390/jcm8091425
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author Arrigo, Alessandro
Romano, Francesco
Albertini, Giorgia
Aragona, Emanuela
Bandello, Francesco
Battaglia Parodi, Maurizio
author_facet Arrigo, Alessandro
Romano, Francesco
Albertini, Giorgia
Aragona, Emanuela
Bandello, Francesco
Battaglia Parodi, Maurizio
author_sort Arrigo, Alessandro
collection PubMed
description Background: Retinitis Pigmentosa (RP) represents a retinal dystrophy with an extremely complex pathogenesis further worsened by the impairment of the retinal vascular supply. The main goal of this study was to identify different vascular patterns in RP, by means of optical coherence tomography angiography (OCTA). Methods: A total of 32 RP patients (16 males, 50%; mean age 45.93 ± 11.4) and 32 healthy age-matched controls (16 males, 50%; age 42.8 ± 11.2). High resolution OCT and OCTA images were obtained from all participants. Several quantitative parameters were extracted both from structural OCT and OCTA images. A post-hoc analysis assessed the relationship between the quantitative OCTA parameters adopted and the following measures: best corrected visual acuity (BCVA), central macular thickness (CMT) and retinal nerve fiber layer (RNFL). Results: Mean LogMAR BCVA was 0.24 ± 0.32 for RP patients and 0.0 ± 0.0 for controls (p < 0.01). CMT, choroidal thickness and RNFL were statistically different between RP and controls (p < 0.01). OCTA parameters showed strong alterations of the retinal vascular network in RP (all p < 0.01). Several statistically significant correlations were also found. Furthermore, a vessel tortuosity cut-off of 4.80 and a vessel rarefaction cut-off of 0.62 enabled the RP cohort to be divided into two significantly different sub-groups in terms of BCVA, RNFL and CMT. Conclusions: Quantitative OCTA parameters help identify vascular abnormalities in RP, separating two different vascular patterns.
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spelling pubmed-67803332019-10-30 Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography Arrigo, Alessandro Romano, Francesco Albertini, Giorgia Aragona, Emanuela Bandello, Francesco Battaglia Parodi, Maurizio J Clin Med Article Background: Retinitis Pigmentosa (RP) represents a retinal dystrophy with an extremely complex pathogenesis further worsened by the impairment of the retinal vascular supply. The main goal of this study was to identify different vascular patterns in RP, by means of optical coherence tomography angiography (OCTA). Methods: A total of 32 RP patients (16 males, 50%; mean age 45.93 ± 11.4) and 32 healthy age-matched controls (16 males, 50%; age 42.8 ± 11.2). High resolution OCT and OCTA images were obtained from all participants. Several quantitative parameters were extracted both from structural OCT and OCTA images. A post-hoc analysis assessed the relationship between the quantitative OCTA parameters adopted and the following measures: best corrected visual acuity (BCVA), central macular thickness (CMT) and retinal nerve fiber layer (RNFL). Results: Mean LogMAR BCVA was 0.24 ± 0.32 for RP patients and 0.0 ± 0.0 for controls (p < 0.01). CMT, choroidal thickness and RNFL were statistically different between RP and controls (p < 0.01). OCTA parameters showed strong alterations of the retinal vascular network in RP (all p < 0.01). Several statistically significant correlations were also found. Furthermore, a vessel tortuosity cut-off of 4.80 and a vessel rarefaction cut-off of 0.62 enabled the RP cohort to be divided into two significantly different sub-groups in terms of BCVA, RNFL and CMT. Conclusions: Quantitative OCTA parameters help identify vascular abnormalities in RP, separating two different vascular patterns. MDPI 2019-09-10 /pmc/articles/PMC6780333/ /pubmed/31510025 http://dx.doi.org/10.3390/jcm8091425 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arrigo, Alessandro
Romano, Francesco
Albertini, Giorgia
Aragona, Emanuela
Bandello, Francesco
Battaglia Parodi, Maurizio
Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography
title Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography
title_full Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography
title_fullStr Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography
title_full_unstemmed Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography
title_short Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography
title_sort vascular patterns in retinitis pigmentosa on swept-source optical coherence tomography angiography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780333/
https://www.ncbi.nlm.nih.gov/pubmed/31510025
http://dx.doi.org/10.3390/jcm8091425
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