Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidati...

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Autores principales: Thomas, Santana A.L., Sanchez, Anthony, Kee, Younghoon, Wilson, Nerida G., Baker, Bill J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780369/
https://www.ncbi.nlm.nih.gov/pubmed/31480497
http://dx.doi.org/10.3390/md17090513
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author Thomas, Santana A.L.
Sanchez, Anthony
Kee, Younghoon
Wilson, Nerida G.
Baker, Bill J.
author_facet Thomas, Santana A.L.
Sanchez, Anthony
Kee, Younghoon
Wilson, Nerida G.
Baker, Bill J.
author_sort Thomas, Santana A.L.
collection PubMed
description An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.
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spelling pubmed-67803692019-10-30 Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879) Thomas, Santana A.L. Sanchez, Anthony Kee, Younghoon Wilson, Nerida G. Baker, Bill J. Mar Drugs Article An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2. MDPI 2019-09-01 /pmc/articles/PMC6780369/ /pubmed/31480497 http://dx.doi.org/10.3390/md17090513 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thomas, Santana A.L.
Sanchez, Anthony
Kee, Younghoon
Wilson, Nerida G.
Baker, Bill J.
Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)
title Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)
title_full Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)
title_fullStr Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)
title_full_unstemmed Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)
title_short Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)
title_sort bathyptilones: terpenoids from an antarctic sea pen, anthoptilum grandiflorum (verrill, 1879)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780369/
https://www.ncbi.nlm.nih.gov/pubmed/31480497
http://dx.doi.org/10.3390/md17090513
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