New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.

Two new steroids, dendronesterones D (1) and E (2), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (3), 5α,8α-epidioxy-24(S)- methylcholesta-6,22-dien-3β-ol (4), and 5α,8α-epidioxy-24(S)-methylcholesta-6,9(11),22-trien-3β-ol (5), were isolate...

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Detalles Bibliográficos
Autores principales: Huynh, Thanh-Hao, Chen, Pei-Chin, Yang, San-Nan, Lin, Feng-Yu, Su, Tung-Pin, Chen, Lo-Yun, Peng, Bo-Rong, Hu, Chiung-Chin, Chen, You-Ying, Wen, Zhi-Hong, Wu, Tung-Ying, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780379/
https://www.ncbi.nlm.nih.gov/pubmed/31514359
http://dx.doi.org/10.3390/md17090530
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author Huynh, Thanh-Hao
Chen, Pei-Chin
Yang, San-Nan
Lin, Feng-Yu
Su, Tung-Pin
Chen, Lo-Yun
Peng, Bo-Rong
Hu, Chiung-Chin
Chen, You-Ying
Wen, Zhi-Hong
Wu, Tung-Ying
Sung, Ping-Jyun
author_facet Huynh, Thanh-Hao
Chen, Pei-Chin
Yang, San-Nan
Lin, Feng-Yu
Su, Tung-Pin
Chen, Lo-Yun
Peng, Bo-Rong
Hu, Chiung-Chin
Chen, You-Ying
Wen, Zhi-Hong
Wu, Tung-Ying
Sung, Ping-Jyun
author_sort Huynh, Thanh-Hao
collection PubMed
description Two new steroids, dendronesterones D (1) and E (2), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (3), 5α,8α-epidioxy-24(S)- methylcholesta-6,22-dien-3β-ol (4), and 5α,8α-epidioxy-24(S)-methylcholesta-6,9(11),22-trien-3β-ol (5), were isolated from an octocoral Dendronephthya sp. The structures of steroids 1 and 2 were elucidated by using spectroscopic methods and steroid 1 was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
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spelling pubmed-67803792019-10-30 New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp. Huynh, Thanh-Hao Chen, Pei-Chin Yang, San-Nan Lin, Feng-Yu Su, Tung-Pin Chen, Lo-Yun Peng, Bo-Rong Hu, Chiung-Chin Chen, You-Ying Wen, Zhi-Hong Wu, Tung-Ying Sung, Ping-Jyun Mar Drugs Article Two new steroids, dendronesterones D (1) and E (2), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (3), 5α,8α-epidioxy-24(S)- methylcholesta-6,22-dien-3β-ol (4), and 5α,8α-epidioxy-24(S)-methylcholesta-6,9(11),22-trien-3β-ol (5), were isolated from an octocoral Dendronephthya sp. The structures of steroids 1 and 2 were elucidated by using spectroscopic methods and steroid 1 was found to exhibit significant in vitro anti-inflammatory activity in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. MDPI 2019-09-11 /pmc/articles/PMC6780379/ /pubmed/31514359 http://dx.doi.org/10.3390/md17090530 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huynh, Thanh-Hao
Chen, Pei-Chin
Yang, San-Nan
Lin, Feng-Yu
Su, Tung-Pin
Chen, Lo-Yun
Peng, Bo-Rong
Hu, Chiung-Chin
Chen, You-Ying
Wen, Zhi-Hong
Wu, Tung-Ying
Sung, Ping-Jyun
New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.
title New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.
title_full New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.
title_fullStr New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.
title_full_unstemmed New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.
title_short New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.
title_sort new 1,4-dienonesteroids from the octocoral dendronephthya sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780379/
https://www.ncbi.nlm.nih.gov/pubmed/31514359
http://dx.doi.org/10.3390/md17090530
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