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Altered Metabolomic Profile in Patients with Peripheral Artery Disease

Peripheral artery disease (PAD) is a common atherosclerotic disease characterized by narrowed or blocked arteries in the lower extremities. Circulating serum biomarkers can provide significant insight regarding the disease progression. Here, we explore the metabolomics signatures associated with dif...

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Autores principales: Ismaeel, Ahmed, Franco, Marco E., Lavado, Ramon, Papoutsi, Evlampia, Casale, George P., Fuglestad, Matthew, Mietus, Constance J., Haynatzki, Gleb R., Smith, Robert S., Bohannon, William T., Sawicki, Ian, Pipinos, Iraklis I., Koutakis, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780416/
https://www.ncbi.nlm.nih.gov/pubmed/31540015
http://dx.doi.org/10.3390/jcm8091463
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author Ismaeel, Ahmed
Franco, Marco E.
Lavado, Ramon
Papoutsi, Evlampia
Casale, George P.
Fuglestad, Matthew
Mietus, Constance J.
Haynatzki, Gleb R.
Smith, Robert S.
Bohannon, William T.
Sawicki, Ian
Pipinos, Iraklis I.
Koutakis, Panagiotis
author_facet Ismaeel, Ahmed
Franco, Marco E.
Lavado, Ramon
Papoutsi, Evlampia
Casale, George P.
Fuglestad, Matthew
Mietus, Constance J.
Haynatzki, Gleb R.
Smith, Robert S.
Bohannon, William T.
Sawicki, Ian
Pipinos, Iraklis I.
Koutakis, Panagiotis
author_sort Ismaeel, Ahmed
collection PubMed
description Peripheral artery disease (PAD) is a common atherosclerotic disease characterized by narrowed or blocked arteries in the lower extremities. Circulating serum biomarkers can provide significant insight regarding the disease progression. Here, we explore the metabolomics signatures associated with different stages of PAD and investigate potential mechanisms of the disease. We compared the serum metabolites of a cohort of 26 PAD patients presenting with claudication and 26 PAD patients presenting with critical limb ischemia (CLI) to those of 26 non-PAD controls. A difference between the metabolite profiles of PAD patients from non-PAD controls was observed for several amino acids, acylcarnitines, ceramides, and cholesteryl esters. Furthermore, our data demonstrate that patients with CLI possess an altered metabolomic signature different from that of both claudicants and non-PAD controls. These findings provide new insight into the pathophysiology of PAD and may help develop future diagnostic procedures and therapies for PAD patients.
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spelling pubmed-67804162019-10-30 Altered Metabolomic Profile in Patients with Peripheral Artery Disease Ismaeel, Ahmed Franco, Marco E. Lavado, Ramon Papoutsi, Evlampia Casale, George P. Fuglestad, Matthew Mietus, Constance J. Haynatzki, Gleb R. Smith, Robert S. Bohannon, William T. Sawicki, Ian Pipinos, Iraklis I. Koutakis, Panagiotis J Clin Med Article Peripheral artery disease (PAD) is a common atherosclerotic disease characterized by narrowed or blocked arteries in the lower extremities. Circulating serum biomarkers can provide significant insight regarding the disease progression. Here, we explore the metabolomics signatures associated with different stages of PAD and investigate potential mechanisms of the disease. We compared the serum metabolites of a cohort of 26 PAD patients presenting with claudication and 26 PAD patients presenting with critical limb ischemia (CLI) to those of 26 non-PAD controls. A difference between the metabolite profiles of PAD patients from non-PAD controls was observed for several amino acids, acylcarnitines, ceramides, and cholesteryl esters. Furthermore, our data demonstrate that patients with CLI possess an altered metabolomic signature different from that of both claudicants and non-PAD controls. These findings provide new insight into the pathophysiology of PAD and may help develop future diagnostic procedures and therapies for PAD patients. MDPI 2019-09-14 /pmc/articles/PMC6780416/ /pubmed/31540015 http://dx.doi.org/10.3390/jcm8091463 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ismaeel, Ahmed
Franco, Marco E.
Lavado, Ramon
Papoutsi, Evlampia
Casale, George P.
Fuglestad, Matthew
Mietus, Constance J.
Haynatzki, Gleb R.
Smith, Robert S.
Bohannon, William T.
Sawicki, Ian
Pipinos, Iraklis I.
Koutakis, Panagiotis
Altered Metabolomic Profile in Patients with Peripheral Artery Disease
title Altered Metabolomic Profile in Patients with Peripheral Artery Disease
title_full Altered Metabolomic Profile in Patients with Peripheral Artery Disease
title_fullStr Altered Metabolomic Profile in Patients with Peripheral Artery Disease
title_full_unstemmed Altered Metabolomic Profile in Patients with Peripheral Artery Disease
title_short Altered Metabolomic Profile in Patients with Peripheral Artery Disease
title_sort altered metabolomic profile in patients with peripheral artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780416/
https://www.ncbi.nlm.nih.gov/pubmed/31540015
http://dx.doi.org/10.3390/jcm8091463
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