Cargando…

Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril

There is an urgent need for new strategies that allow the simultaneous detection and control of drug delivery. By making use of supramolecular host-guest interactions, a kind of pseudopolyrotaxanes, as a visualizable nanoscale drug carrier has been constructed by self-assembly of cucurbit[7]uril (CB...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Xiumin, Wang, Xin, Hou, Shengzhen, Zhang, Jin, Zhou, Jing, Tan, Yebang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780542/
https://www.ncbi.nlm.nih.gov/pubmed/31505799
http://dx.doi.org/10.3390/polym11091470
_version_ 1783457160453160960
author Qiu, Xiumin
Wang, Xin
Hou, Shengzhen
Zhang, Jin
Zhou, Jing
Tan, Yebang
author_facet Qiu, Xiumin
Wang, Xin
Hou, Shengzhen
Zhang, Jin
Zhou, Jing
Tan, Yebang
author_sort Qiu, Xiumin
collection PubMed
description There is an urgent need for new strategies that allow the simultaneous detection and control of drug delivery. By making use of supramolecular host-guest interactions, a kind of pseudopolyrotaxanes, as a visualizable nanoscale drug carrier has been constructed by self-assembly of cucurbit[7]uril (CB[7]) with methoxy poly(ethylene glycol)-block-quaternized poly(4-vinyl pyridine) (mPEG-b-QP4VP) using 4-(chloromethyl)benzonitrile. Simple addition of CB[7] into an aqueous solution of mPEG-b-QP4VP resulted in noncovalent attachment of CB[7] to 4-cyanobenzyl-containing polymers, transforming the nonemissive mPEG-b-QP4VP micelles into highly fluorescent micelles. These pseudopolyrotaxanes micelles exhibited remarkable supramolecular assembly-induced emission enhancement and excellent biocompatibility, showing great potential for bioimaging applications. In addition, the efficient cellular uptake of the developed pseudopolyrotaxanes micelles loaded with the anticancer drug doxorubicin was a promising platform for simultaneous cell imaging and drug delivery, thereby widening their application in cancer theranostics.
format Online
Article
Text
id pubmed-6780542
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67805422019-10-30 Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril Qiu, Xiumin Wang, Xin Hou, Shengzhen Zhang, Jin Zhou, Jing Tan, Yebang Polymers (Basel) Article There is an urgent need for new strategies that allow the simultaneous detection and control of drug delivery. By making use of supramolecular host-guest interactions, a kind of pseudopolyrotaxanes, as a visualizable nanoscale drug carrier has been constructed by self-assembly of cucurbit[7]uril (CB[7]) with methoxy poly(ethylene glycol)-block-quaternized poly(4-vinyl pyridine) (mPEG-b-QP4VP) using 4-(chloromethyl)benzonitrile. Simple addition of CB[7] into an aqueous solution of mPEG-b-QP4VP resulted in noncovalent attachment of CB[7] to 4-cyanobenzyl-containing polymers, transforming the nonemissive mPEG-b-QP4VP micelles into highly fluorescent micelles. These pseudopolyrotaxanes micelles exhibited remarkable supramolecular assembly-induced emission enhancement and excellent biocompatibility, showing great potential for bioimaging applications. In addition, the efficient cellular uptake of the developed pseudopolyrotaxanes micelles loaded with the anticancer drug doxorubicin was a promising platform for simultaneous cell imaging and drug delivery, thereby widening their application in cancer theranostics. MDPI 2019-09-09 /pmc/articles/PMC6780542/ /pubmed/31505799 http://dx.doi.org/10.3390/polym11091470 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qiu, Xiumin
Wang, Xin
Hou, Shengzhen
Zhang, Jin
Zhou, Jing
Tan, Yebang
Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril
title Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril
title_full Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril
title_fullStr Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril
title_full_unstemmed Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril
title_short Tunable Fluorescence-Responsive Double Hydrophilic Block Polymers Induced by the Formation of Pseudopolyrotaxanes with Cucurbit[7]Uril
title_sort tunable fluorescence-responsive double hydrophilic block polymers induced by the formation of pseudopolyrotaxanes with cucurbit[7]uril
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780542/
https://www.ncbi.nlm.nih.gov/pubmed/31505799
http://dx.doi.org/10.3390/polym11091470
work_keys_str_mv AT qiuxiumin tunablefluorescenceresponsivedoublehydrophilicblockpolymersinducedbytheformationofpseudopolyrotaxaneswithcucurbit7uril
AT wangxin tunablefluorescenceresponsivedoublehydrophilicblockpolymersinducedbytheformationofpseudopolyrotaxaneswithcucurbit7uril
AT houshengzhen tunablefluorescenceresponsivedoublehydrophilicblockpolymersinducedbytheformationofpseudopolyrotaxaneswithcucurbit7uril
AT zhangjin tunablefluorescenceresponsivedoublehydrophilicblockpolymersinducedbytheformationofpseudopolyrotaxaneswithcucurbit7uril
AT zhoujing tunablefluorescenceresponsivedoublehydrophilicblockpolymersinducedbytheformationofpseudopolyrotaxaneswithcucurbit7uril
AT tanyebang tunablefluorescenceresponsivedoublehydrophilicblockpolymersinducedbytheformationofpseudopolyrotaxaneswithcucurbit7uril