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Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland

The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters we...

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Autores principales: Grasl, Stefan, Janik, Stefan, Grasl, Matthaeus C., Pammer, Johannes, Formanek, Michael, Weinreb, Ilan, Perez-Ordonez, Bayardo, Hope, Andrew, Hosni, Ali, de Almeida, John R., Irish, Jon, Gilbert, Ralph, Goldstein, David P., Erovic, Boban M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780641/
https://www.ncbi.nlm.nih.gov/pubmed/31461946
http://dx.doi.org/10.3390/jcm8091315
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author Grasl, Stefan
Janik, Stefan
Grasl, Matthaeus C.
Pammer, Johannes
Formanek, Michael
Weinreb, Ilan
Perez-Ordonez, Bayardo
Hope, Andrew
Hosni, Ali
de Almeida, John R.
Irish, Jon
Gilbert, Ralph
Goldstein, David P.
Erovic, Boban M.
author_facet Grasl, Stefan
Janik, Stefan
Grasl, Matthaeus C.
Pammer, Johannes
Formanek, Michael
Weinreb, Ilan
Perez-Ordonez, Bayardo
Hope, Andrew
Hosni, Ali
de Almeida, John R.
Irish, Jon
Gilbert, Ralph
Goldstein, David P.
Erovic, Boban M.
author_sort Grasl, Stefan
collection PubMed
description The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69–44.01; p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01–0.37; p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02–0.59; p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.
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spelling pubmed-67806412019-10-30 Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland Grasl, Stefan Janik, Stefan Grasl, Matthaeus C. Pammer, Johannes Formanek, Michael Weinreb, Ilan Perez-Ordonez, Bayardo Hope, Andrew Hosni, Ali de Almeida, John R. Irish, Jon Gilbert, Ralph Goldstein, David P. Erovic, Boban M. J Clin Med Article The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69–44.01; p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01–0.37; p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02–0.59; p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes. MDPI 2019-08-27 /pmc/articles/PMC6780641/ /pubmed/31461946 http://dx.doi.org/10.3390/jcm8091315 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grasl, Stefan
Janik, Stefan
Grasl, Matthaeus C.
Pammer, Johannes
Formanek, Michael
Weinreb, Ilan
Perez-Ordonez, Bayardo
Hope, Andrew
Hosni, Ali
de Almeida, John R.
Irish, Jon
Gilbert, Ralph
Goldstein, David P.
Erovic, Boban M.
Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_full Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_fullStr Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_full_unstemmed Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_short Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland
title_sort nodal metastases in acinic cell carcinoma of the parotid gland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780641/
https://www.ncbi.nlm.nih.gov/pubmed/31461946
http://dx.doi.org/10.3390/jcm8091315
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