New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

Three new 8-hydroxybriaranes—fragilides R–T (1–3) were obtained from a sea whip gorgonian coral Junceella fragilis. The structures of briaranes 1–3 were elucidated by using spectroscopic methods, including 1D ((1)H and (13)C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRE...

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Detalles Bibliográficos
Autores principales: Chen, You-Ying, Fang, Lee-Shing, Chen, Yu-Hsin, Peng, Bo-Rong, Su, Tung-Pin, Huynh, Thanh-Hao, Lin, Feng-Yu, Hu, Chiung-Chin, Lin, Nai-Cheng, Wen, Zhi-Hong, Chen, Jih-Jung, Lee, Chieh-Yu, Wang, Jin-Wei, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780648/
https://www.ncbi.nlm.nih.gov/pubmed/31540107
http://dx.doi.org/10.3390/md17090534
Descripción
Sumario:Three new 8-hydroxybriaranes—fragilides R–T (1–3) were obtained from a sea whip gorgonian coral Junceella fragilis. The structures of briaranes 1–3 were elucidated by using spectroscopic methods, including 1D ((1)H and (13)C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (2 and 3) are the only briaranes known to possess 8α-hydroxy and 17β-methyl groups, respectively. Briarane 2 exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.

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