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The Skin in Celiac Disease Patients: The Other Side of the Coin

Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifes...

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Autores principales: Abenavoli, Ludovico, Dastoli, Stefano, Bennardo, Luigi, Boccuto, Luigi, Passante, Maria, Silvestri, Martina, Proietti, Ilaria, Potenza, Concetta, Luzza, Francesco, Nisticò, Steven Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780714/
https://www.ncbi.nlm.nih.gov/pubmed/31505858
http://dx.doi.org/10.3390/medicina55090578
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author Abenavoli, Ludovico
Dastoli, Stefano
Bennardo, Luigi
Boccuto, Luigi
Passante, Maria
Silvestri, Martina
Proietti, Ilaria
Potenza, Concetta
Luzza, Francesco
Nisticò, Steven Paul
author_facet Abenavoli, Ludovico
Dastoli, Stefano
Bennardo, Luigi
Boccuto, Luigi
Passante, Maria
Silvestri, Martina
Proietti, Ilaria
Potenza, Concetta
Luzza, Francesco
Nisticò, Steven Paul
author_sort Abenavoli, Ludovico
collection PubMed
description Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required.
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spelling pubmed-67807142019-10-30 The Skin in Celiac Disease Patients: The Other Side of the Coin Abenavoli, Ludovico Dastoli, Stefano Bennardo, Luigi Boccuto, Luigi Passante, Maria Silvestri, Martina Proietti, Ilaria Potenza, Concetta Luzza, Francesco Nisticò, Steven Paul Medicina (Kaunas) Review Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required. MDPI 2019-09-09 /pmc/articles/PMC6780714/ /pubmed/31505858 http://dx.doi.org/10.3390/medicina55090578 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abenavoli, Ludovico
Dastoli, Stefano
Bennardo, Luigi
Boccuto, Luigi
Passante, Maria
Silvestri, Martina
Proietti, Ilaria
Potenza, Concetta
Luzza, Francesco
Nisticò, Steven Paul
The Skin in Celiac Disease Patients: The Other Side of the Coin
title The Skin in Celiac Disease Patients: The Other Side of the Coin
title_full The Skin in Celiac Disease Patients: The Other Side of the Coin
title_fullStr The Skin in Celiac Disease Patients: The Other Side of the Coin
title_full_unstemmed The Skin in Celiac Disease Patients: The Other Side of the Coin
title_short The Skin in Celiac Disease Patients: The Other Side of the Coin
title_sort skin in celiac disease patients: the other side of the coin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780714/
https://www.ncbi.nlm.nih.gov/pubmed/31505858
http://dx.doi.org/10.3390/medicina55090578
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