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Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol

Chitosan oleate (CS-OA), a chitosan salt with amphiphilic properties, has demonstrated the ability to self-assemble in aqueous environment to give polymeric micelles useful to load poorly soluble drugs. More recently, CS-OA was proposed to stabilize nanoemulsions during the preparation by emulsifica...

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Autores principales: Miele, Dalila, Catenacci, Laura, Sorrenti, Milena, Rossi, Silvia, Sandri, Giuseppina, Malavasi, Lorenzo, Dacarro, Giacomo, Ferrari, Franca, Bonferoni, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780743/
https://www.ncbi.nlm.nih.gov/pubmed/31480614
http://dx.doi.org/10.3390/md17090515
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author Miele, Dalila
Catenacci, Laura
Sorrenti, Milena
Rossi, Silvia
Sandri, Giuseppina
Malavasi, Lorenzo
Dacarro, Giacomo
Ferrari, Franca
Bonferoni, Maria Cristina
author_facet Miele, Dalila
Catenacci, Laura
Sorrenti, Milena
Rossi, Silvia
Sandri, Giuseppina
Malavasi, Lorenzo
Dacarro, Giacomo
Ferrari, Franca
Bonferoni, Maria Cristina
author_sort Miele, Dalila
collection PubMed
description Chitosan oleate (CS-OA), a chitosan salt with amphiphilic properties, has demonstrated the ability to self-assemble in aqueous environment to give polymeric micelles useful to load poorly soluble drugs. More recently, CS-OA was proposed to stabilize nanoemulsions during the preparation by emulsification and solvent evaporation of poly lactic-glycolic acid (PLGA) nanoparticles (NPs) loaded with curcumin. Positive mucoadhesive behavior and internalization properties were demonstrated for these NPs attributable to the presence of positive charge at the NP surface. In the present paper, two CS-OA-based nanosystems, micelles and PLGA NPs, were compared with the aim of elucidating their physico-chemical characteristics, and especially their interaction with cell substrates. The two systems were loaded with resveratrol (RSV), a hydrophobic polyphenol endowed with anti-cancerogenic, anti-inflammatory, and heart/brain protective effects, but with low bioavailability mainly due to poor aqueous solubility. Calorimetric analysis and X-ray spectra demonstrated amorphization of RSV, confirming its affinity for hydrophobic domains of polymeric micelles and PLGA core of NPs. TGA decomposition patterns suggest higher stability of PLGA-NPs compared with polymeric micelles, that anyway resulted more stable than expected, considering the RSV release profiles, and the cell line interaction results.
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spelling pubmed-67807432019-10-30 Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol Miele, Dalila Catenacci, Laura Sorrenti, Milena Rossi, Silvia Sandri, Giuseppina Malavasi, Lorenzo Dacarro, Giacomo Ferrari, Franca Bonferoni, Maria Cristina Mar Drugs Article Chitosan oleate (CS-OA), a chitosan salt with amphiphilic properties, has demonstrated the ability to self-assemble in aqueous environment to give polymeric micelles useful to load poorly soluble drugs. More recently, CS-OA was proposed to stabilize nanoemulsions during the preparation by emulsification and solvent evaporation of poly lactic-glycolic acid (PLGA) nanoparticles (NPs) loaded with curcumin. Positive mucoadhesive behavior and internalization properties were demonstrated for these NPs attributable to the presence of positive charge at the NP surface. In the present paper, two CS-OA-based nanosystems, micelles and PLGA NPs, were compared with the aim of elucidating their physico-chemical characteristics, and especially their interaction with cell substrates. The two systems were loaded with resveratrol (RSV), a hydrophobic polyphenol endowed with anti-cancerogenic, anti-inflammatory, and heart/brain protective effects, but with low bioavailability mainly due to poor aqueous solubility. Calorimetric analysis and X-ray spectra demonstrated amorphization of RSV, confirming its affinity for hydrophobic domains of polymeric micelles and PLGA core of NPs. TGA decomposition patterns suggest higher stability of PLGA-NPs compared with polymeric micelles, that anyway resulted more stable than expected, considering the RSV release profiles, and the cell line interaction results. MDPI 2019-09-01 /pmc/articles/PMC6780743/ /pubmed/31480614 http://dx.doi.org/10.3390/md17090515 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miele, Dalila
Catenacci, Laura
Sorrenti, Milena
Rossi, Silvia
Sandri, Giuseppina
Malavasi, Lorenzo
Dacarro, Giacomo
Ferrari, Franca
Bonferoni, Maria Cristina
Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol
title Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol
title_full Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol
title_fullStr Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol
title_full_unstemmed Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol
title_short Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) Nanoparticles versus Chitosan Oleate Self-Assembled Polymeric Micelles, Loaded with Resveratrol
title_sort chitosan oleate coated poly lactic-glycolic acid (plga) nanoparticles versus chitosan oleate self-assembled polymeric micelles, loaded with resveratrol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780743/
https://www.ncbi.nlm.nih.gov/pubmed/31480614
http://dx.doi.org/10.3390/md17090515
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