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Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers

In this study, gelatin and pullulan were successfully prepared as a novel type of protein–polysaccharide composite nanofibrous membrane by electrospinning at room temperature with deionized water as the solvent. The effects of gelatin content on the properties of the solution, as well as the morphol...

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Autores principales: Wang, Yuanduo, Guo, Ziyang, Qian, Yongfang, Zhang, Zhen, Lyu, Lihua, Wang, Ying, Ye, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780768/
https://www.ncbi.nlm.nih.gov/pubmed/31480275
http://dx.doi.org/10.3390/polym11091424
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author Wang, Yuanduo
Guo, Ziyang
Qian, Yongfang
Zhang, Zhen
Lyu, Lihua
Wang, Ying
Ye, Fang
author_facet Wang, Yuanduo
Guo, Ziyang
Qian, Yongfang
Zhang, Zhen
Lyu, Lihua
Wang, Ying
Ye, Fang
author_sort Wang, Yuanduo
collection PubMed
description In this study, gelatin and pullulan were successfully prepared as a novel type of protein–polysaccharide composite nanofibrous membrane by electrospinning at room temperature with deionized water as the solvent. The effects of gelatin content on the properties of the solution, as well as the morphology of the resultant nanofibers, were investigated. Scanning electron microscopy (SEM) was utilized to observe the surface morphology. Fourier transform infrared spectroscopy (FTIR) was used to study the interaction between gelatin and pullulan. Incorporation of pullulan with gelatin will improve the spinnability of the mixed aqueous solution due to lower surface tension. Moreover, the conductivity of the solution had a greater effect on the fiber diameters, and the as-spun fibers became thinner as the viscosity and the surface tension increased due to the addition of the polyelectrolyte gelatin. Gelatin and pullulan formed hydrogen bonds, and the intermolecular hydrogen bonds increased while the intramolecular hydrogen bond decreased, which resulted in better mechanical properties. The electrospun gelatin/pullulan nanofibers could mimic both the structure and the composition of the extracellular matrix, and thus could be applied in tissue engineering.
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spelling pubmed-67807682019-10-30 Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers Wang, Yuanduo Guo, Ziyang Qian, Yongfang Zhang, Zhen Lyu, Lihua Wang, Ying Ye, Fang Polymers (Basel) Article In this study, gelatin and pullulan were successfully prepared as a novel type of protein–polysaccharide composite nanofibrous membrane by electrospinning at room temperature with deionized water as the solvent. The effects of gelatin content on the properties of the solution, as well as the morphology of the resultant nanofibers, were investigated. Scanning electron microscopy (SEM) was utilized to observe the surface morphology. Fourier transform infrared spectroscopy (FTIR) was used to study the interaction between gelatin and pullulan. Incorporation of pullulan with gelatin will improve the spinnability of the mixed aqueous solution due to lower surface tension. Moreover, the conductivity of the solution had a greater effect on the fiber diameters, and the as-spun fibers became thinner as the viscosity and the surface tension increased due to the addition of the polyelectrolyte gelatin. Gelatin and pullulan formed hydrogen bonds, and the intermolecular hydrogen bonds increased while the intramolecular hydrogen bond decreased, which resulted in better mechanical properties. The electrospun gelatin/pullulan nanofibers could mimic both the structure and the composition of the extracellular matrix, and thus could be applied in tissue engineering. MDPI 2019-08-30 /pmc/articles/PMC6780768/ /pubmed/31480275 http://dx.doi.org/10.3390/polym11091424 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Yuanduo
Guo, Ziyang
Qian, Yongfang
Zhang, Zhen
Lyu, Lihua
Wang, Ying
Ye, Fang
Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers
title Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers
title_full Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers
title_fullStr Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers
title_full_unstemmed Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers
title_short Study on the Electrospinning of Gelatin/Pullulan Composite Nanofibers
title_sort study on the electrospinning of gelatin/pullulan composite nanofibers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780768/
https://www.ncbi.nlm.nih.gov/pubmed/31480275
http://dx.doi.org/10.3390/polym11091424
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