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Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice

Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate th...

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Autores principales: Matsumoto, Yutaka, Ma, Sihui, Tominaga, Takaki, Yokoyama, Keiko, Kitatani, Kanae, Horikawa, Kazumasa, Suzuki, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780807/
https://www.ncbi.nlm.nih.gov/pubmed/31540183
http://dx.doi.org/10.3390/medicina55090594
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author Matsumoto, Yutaka
Ma, Sihui
Tominaga, Takaki
Yokoyama, Keiko
Kitatani, Kanae
Horikawa, Kazumasa
Suzuki, Katsuhiko
author_facet Matsumoto, Yutaka
Ma, Sihui
Tominaga, Takaki
Yokoyama, Keiko
Kitatani, Kanae
Horikawa, Kazumasa
Suzuki, Katsuhiko
author_sort Matsumoto, Yutaka
collection PubMed
description Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Materials and Methods: Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Atgl was significantly upregulated in the liver (p < 0.05), and Atgl upregulation in the liver was positively correlated with serum NEFA levels (r = 0.592, p < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (FABPpm, FATP-1, FATP-3, and FATP-4) expression in the skin after topical application of jojoba oil (p = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.
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spelling pubmed-67808072019-10-30 Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice Matsumoto, Yutaka Ma, Sihui Tominaga, Takaki Yokoyama, Keiko Kitatani, Kanae Horikawa, Kazumasa Suzuki, Katsuhiko Medicina (Kaunas) Article Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Materials and Methods: Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Atgl was significantly upregulated in the liver (p < 0.05), and Atgl upregulation in the liver was positively correlated with serum NEFA levels (r = 0.592, p < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (FABPpm, FATP-1, FATP-3, and FATP-4) expression in the skin after topical application of jojoba oil (p = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin. MDPI 2019-09-15 /pmc/articles/PMC6780807/ /pubmed/31540183 http://dx.doi.org/10.3390/medicina55090594 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsumoto, Yutaka
Ma, Sihui
Tominaga, Takaki
Yokoyama, Keiko
Kitatani, Kanae
Horikawa, Kazumasa
Suzuki, Katsuhiko
Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice
title Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice
title_full Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice
title_fullStr Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice
title_full_unstemmed Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice
title_short Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice
title_sort acute effects of transdermal administration of jojoba oil on lipid metabolism in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780807/
https://www.ncbi.nlm.nih.gov/pubmed/31540183
http://dx.doi.org/10.3390/medicina55090594
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