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Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP

The objective of this study is to evaluate the risk of clinical infections by herpesviruses in patients exposed to valproic acid (VPA). We performed a case-control study nested in a primary cohort selected from the Spanish primary care population-based research database BIFAP (Base de datos para la...

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Autores principales: Gil, Miguel, González-González, Rocío, Vázquez-Calvo, Angela, Álvarez-Gutiérrez, Arturo, Martín-Acebes, Miguel A., Praena, Beatriz, Bello-Morales, Raquel, Saiz, Juan-Carlos, López-Guerrero, Jose A., Tabarés, Enrique, Sobrino, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780826/
https://www.ncbi.nlm.nih.gov/pubmed/31514402
http://dx.doi.org/10.3390/jcm8091442
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author Gil, Miguel
González-González, Rocío
Vázquez-Calvo, Angela
Álvarez-Gutiérrez, Arturo
Martín-Acebes, Miguel A.
Praena, Beatriz
Bello-Morales, Raquel
Saiz, Juan-Carlos
López-Guerrero, Jose A.
Tabarés, Enrique
Sobrino, Francisco
author_facet Gil, Miguel
González-González, Rocío
Vázquez-Calvo, Angela
Álvarez-Gutiérrez, Arturo
Martín-Acebes, Miguel A.
Praena, Beatriz
Bello-Morales, Raquel
Saiz, Juan-Carlos
López-Guerrero, Jose A.
Tabarés, Enrique
Sobrino, Francisco
author_sort Gil, Miguel
collection PubMed
description The objective of this study is to evaluate the risk of clinical infections by herpesviruses in patients exposed to valproic acid (VPA). We performed a case-control study nested in a primary cohort selected from the Spanish primary care population-based research database BIFAP (Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria) over the period 2001–2015. The events of interest were those diseases caused by any herpesviruses known to infect humans. For each case, up to 10 controls per case matched by age, gender, and calendar date were randomly selected. A conditional logistic regression was used to compute adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). Current use of VPA was associated with a trend towards a reduced risk of clinical infections by herpesviruses as compared with non-users (OR 0.84; CI 95% 0.7–1.0; p = 0.057). Among current users, a trend to a decreased risk with treatment durations longer than 90 days was also observed. The results show a trend to a reduced risk of clinical infection by herpesviruses in patients exposed to VPA. These results are consistent with those in vitro studies showing that, in cultured cells, VPA can inhibit the production of the infectious progeny of herpesviruses. This study also shows the efficient use of electronic healthcare records for clinical exploratory research studies.
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spelling pubmed-67808262019-10-30 Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP Gil, Miguel González-González, Rocío Vázquez-Calvo, Angela Álvarez-Gutiérrez, Arturo Martín-Acebes, Miguel A. Praena, Beatriz Bello-Morales, Raquel Saiz, Juan-Carlos López-Guerrero, Jose A. Tabarés, Enrique Sobrino, Francisco J Clin Med Article The objective of this study is to evaluate the risk of clinical infections by herpesviruses in patients exposed to valproic acid (VPA). We performed a case-control study nested in a primary cohort selected from the Spanish primary care population-based research database BIFAP (Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria) over the period 2001–2015. The events of interest were those diseases caused by any herpesviruses known to infect humans. For each case, up to 10 controls per case matched by age, gender, and calendar date were randomly selected. A conditional logistic regression was used to compute adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). Current use of VPA was associated with a trend towards a reduced risk of clinical infections by herpesviruses as compared with non-users (OR 0.84; CI 95% 0.7–1.0; p = 0.057). Among current users, a trend to a decreased risk with treatment durations longer than 90 days was also observed. The results show a trend to a reduced risk of clinical infection by herpesviruses in patients exposed to VPA. These results are consistent with those in vitro studies showing that, in cultured cells, VPA can inhibit the production of the infectious progeny of herpesviruses. This study also shows the efficient use of electronic healthcare records for clinical exploratory research studies. MDPI 2019-09-11 /pmc/articles/PMC6780826/ /pubmed/31514402 http://dx.doi.org/10.3390/jcm8091442 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gil, Miguel
González-González, Rocío
Vázquez-Calvo, Angela
Álvarez-Gutiérrez, Arturo
Martín-Acebes, Miguel A.
Praena, Beatriz
Bello-Morales, Raquel
Saiz, Juan-Carlos
López-Guerrero, Jose A.
Tabarés, Enrique
Sobrino, Francisco
Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP
title Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP
title_full Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP
title_fullStr Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP
title_full_unstemmed Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP
title_short Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP
title_sort clinical infections by herpesviruses in patients treated with valproic acid: a nested case-control study in the spanish primary care database, bifap
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780826/
https://www.ncbi.nlm.nih.gov/pubmed/31514402
http://dx.doi.org/10.3390/jcm8091442
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