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Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP
The objective of this study is to evaluate the risk of clinical infections by herpesviruses in patients exposed to valproic acid (VPA). We performed a case-control study nested in a primary cohort selected from the Spanish primary care population-based research database BIFAP (Base de datos para la...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780826/ https://www.ncbi.nlm.nih.gov/pubmed/31514402 http://dx.doi.org/10.3390/jcm8091442 |
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author | Gil, Miguel González-González, Rocío Vázquez-Calvo, Angela Álvarez-Gutiérrez, Arturo Martín-Acebes, Miguel A. Praena, Beatriz Bello-Morales, Raquel Saiz, Juan-Carlos López-Guerrero, Jose A. Tabarés, Enrique Sobrino, Francisco |
author_facet | Gil, Miguel González-González, Rocío Vázquez-Calvo, Angela Álvarez-Gutiérrez, Arturo Martín-Acebes, Miguel A. Praena, Beatriz Bello-Morales, Raquel Saiz, Juan-Carlos López-Guerrero, Jose A. Tabarés, Enrique Sobrino, Francisco |
author_sort | Gil, Miguel |
collection | PubMed |
description | The objective of this study is to evaluate the risk of clinical infections by herpesviruses in patients exposed to valproic acid (VPA). We performed a case-control study nested in a primary cohort selected from the Spanish primary care population-based research database BIFAP (Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria) over the period 2001–2015. The events of interest were those diseases caused by any herpesviruses known to infect humans. For each case, up to 10 controls per case matched by age, gender, and calendar date were randomly selected. A conditional logistic regression was used to compute adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). Current use of VPA was associated with a trend towards a reduced risk of clinical infections by herpesviruses as compared with non-users (OR 0.84; CI 95% 0.7–1.0; p = 0.057). Among current users, a trend to a decreased risk with treatment durations longer than 90 days was also observed. The results show a trend to a reduced risk of clinical infection by herpesviruses in patients exposed to VPA. These results are consistent with those in vitro studies showing that, in cultured cells, VPA can inhibit the production of the infectious progeny of herpesviruses. This study also shows the efficient use of electronic healthcare records for clinical exploratory research studies. |
format | Online Article Text |
id | pubmed-6780826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67808262019-10-30 Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP Gil, Miguel González-González, Rocío Vázquez-Calvo, Angela Álvarez-Gutiérrez, Arturo Martín-Acebes, Miguel A. Praena, Beatriz Bello-Morales, Raquel Saiz, Juan-Carlos López-Guerrero, Jose A. Tabarés, Enrique Sobrino, Francisco J Clin Med Article The objective of this study is to evaluate the risk of clinical infections by herpesviruses in patients exposed to valproic acid (VPA). We performed a case-control study nested in a primary cohort selected from the Spanish primary care population-based research database BIFAP (Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria) over the period 2001–2015. The events of interest were those diseases caused by any herpesviruses known to infect humans. For each case, up to 10 controls per case matched by age, gender, and calendar date were randomly selected. A conditional logistic regression was used to compute adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). Current use of VPA was associated with a trend towards a reduced risk of clinical infections by herpesviruses as compared with non-users (OR 0.84; CI 95% 0.7–1.0; p = 0.057). Among current users, a trend to a decreased risk with treatment durations longer than 90 days was also observed. The results show a trend to a reduced risk of clinical infection by herpesviruses in patients exposed to VPA. These results are consistent with those in vitro studies showing that, in cultured cells, VPA can inhibit the production of the infectious progeny of herpesviruses. This study also shows the efficient use of electronic healthcare records for clinical exploratory research studies. MDPI 2019-09-11 /pmc/articles/PMC6780826/ /pubmed/31514402 http://dx.doi.org/10.3390/jcm8091442 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gil, Miguel González-González, Rocío Vázquez-Calvo, Angela Álvarez-Gutiérrez, Arturo Martín-Acebes, Miguel A. Praena, Beatriz Bello-Morales, Raquel Saiz, Juan-Carlos López-Guerrero, Jose A. Tabarés, Enrique Sobrino, Francisco Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP |
title | Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP |
title_full | Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP |
title_fullStr | Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP |
title_full_unstemmed | Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP |
title_short | Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP |
title_sort | clinical infections by herpesviruses in patients treated with valproic acid: a nested case-control study in the spanish primary care database, bifap |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780826/ https://www.ncbi.nlm.nih.gov/pubmed/31514402 http://dx.doi.org/10.3390/jcm8091442 |
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