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Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat

Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired atten...

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Autores principales: Kim, Ran, Hur, Daeun, Kim, Hyoung Kyu, Han, Jin, Mishchenko, Natalia P., Fedoreyev, Sergey A., Stonik, Valentin A., Chang, Woochul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780833/
https://www.ncbi.nlm.nih.gov/pubmed/31466244
http://dx.doi.org/10.3390/md17090501
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author Kim, Ran
Hur, Daeun
Kim, Hyoung Kyu
Han, Jin
Mishchenko, Natalia P.
Fedoreyev, Sergey A.
Stonik, Valentin A.
Chang, Woochul
author_facet Kim, Ran
Hur, Daeun
Kim, Hyoung Kyu
Han, Jin
Mishchenko, Natalia P.
Fedoreyev, Sergey A.
Stonik, Valentin A.
Chang, Woochul
author_sort Kim, Ran
collection PubMed
description Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired attention as an alternative clinical trial source for the treatment of ischemic stroke. The current study demonstrates considerable potential of Ech A as a medication for cerebral ischemic injury. To confirm the effects of Ech A on the recovery of the injured region and behavioral decline, Ech A was administered through the external carotid artery in a rat middle cerebral artery occlusion model after reperfusion. The expression level of cell viability-related factors was also examined to confirm the mechanism of brain physiological restoration. Based on the results obtained, we propose that Ech A ameliorates the physiological deterioration by its antioxidant effect which plays a protective role against cell death, subsequent to post cerebral ischemic stroke.
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spelling pubmed-67808332019-10-30 Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat Kim, Ran Hur, Daeun Kim, Hyoung Kyu Han, Jin Mishchenko, Natalia P. Fedoreyev, Sergey A. Stonik, Valentin A. Chang, Woochul Mar Drugs Article Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired attention as an alternative clinical trial source for the treatment of ischemic stroke. The current study demonstrates considerable potential of Ech A as a medication for cerebral ischemic injury. To confirm the effects of Ech A on the recovery of the injured region and behavioral decline, Ech A was administered through the external carotid artery in a rat middle cerebral artery occlusion model after reperfusion. The expression level of cell viability-related factors was also examined to confirm the mechanism of brain physiological restoration. Based on the results obtained, we propose that Ech A ameliorates the physiological deterioration by its antioxidant effect which plays a protective role against cell death, subsequent to post cerebral ischemic stroke. MDPI 2019-08-28 /pmc/articles/PMC6780833/ /pubmed/31466244 http://dx.doi.org/10.3390/md17090501 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Ran
Hur, Daeun
Kim, Hyoung Kyu
Han, Jin
Mishchenko, Natalia P.
Fedoreyev, Sergey A.
Stonik, Valentin A.
Chang, Woochul
Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
title Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
title_full Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
title_fullStr Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
title_full_unstemmed Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
title_short Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
title_sort echinochrome a attenuates cerebral ischemic injury through regulation of cell survival after middle cerebral artery occlusion in rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780833/
https://www.ncbi.nlm.nih.gov/pubmed/31466244
http://dx.doi.org/10.3390/md17090501
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