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Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus

Background and objectives: Diabetes mellitus represents a metabolic disorder the incidence of which has been on the increase in recent years. The well-known long-term complications of this disease encompass a wide spectrum of renal, neurological and cardiovascular conditions. The aim of the study wa...

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Autores principales: Dec-Gilowska, Malgorzata, Trojnar, Marcin, Makaruk, Boguslaw, Czop, Marcin, Przybylska-Kuc, Sylwia, Mosiewicz-Madejska, Barbara, Dzida, Grzegorz, Mosiewicz, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780956/
https://www.ncbi.nlm.nih.gov/pubmed/31527473
http://dx.doi.org/10.3390/medicina55090596
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author Dec-Gilowska, Malgorzata
Trojnar, Marcin
Makaruk, Boguslaw
Czop, Marcin
Przybylska-Kuc, Sylwia
Mosiewicz-Madejska, Barbara
Dzida, Grzegorz
Mosiewicz, Jerzy
author_facet Dec-Gilowska, Malgorzata
Trojnar, Marcin
Makaruk, Boguslaw
Czop, Marcin
Przybylska-Kuc, Sylwia
Mosiewicz-Madejska, Barbara
Dzida, Grzegorz
Mosiewicz, Jerzy
author_sort Dec-Gilowska, Malgorzata
collection PubMed
description Background and objectives: Diabetes mellitus represents a metabolic disorder the incidence of which has been on the increase in recent years. The well-known long-term complications of this disease encompass a wide spectrum of renal, neurological and cardiovascular conditions. The aim of the study was to investigate the serum concentration of endothelial microparticles (EMPs) as well as selected noninvasive parameters of the ascending aorta stiffness calculated with echocardiography. Materials and Methods: 58 patients were enrolled in this study—38 subjects diagnosed with type 2 diabetes mellitus (T2DM) and 20 healthy controls. The analyzed populations did not differ significantly with respect to age, renal function, systolic and diastolic blood pressure. Results: The patients with T2DM and concomitant hypertension presented higher levels of EMPs in comparison with diabetic normotensive subjects. Among patients with T2DM and hypertension, aortic stiffness assessed with the elasticity index (Ep) was higher and the aortic compliance index (D) lower than in the diabetic normotensive group. No correlation between the amount of EMPs and lipid profile, C-reactive protein (CRP) level and glycemia, was observed in the studied group. There was, however, a statistically significant positive correlation between the creatinine level and amount of EMPs, while the negative relationship was documented for EMPs level and the estimated glomerular filtration rate (eGFR). Conclusions: Considering the elevated number of EMPs in diabetic patients with hypertension as well as the positive correlation between EMPs and serum creatinine level, EMPs assessment could be useful in identifying patients who are at high risk of organ damage due to diabetes mellitus.
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spelling pubmed-67809562019-10-30 Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus Dec-Gilowska, Malgorzata Trojnar, Marcin Makaruk, Boguslaw Czop, Marcin Przybylska-Kuc, Sylwia Mosiewicz-Madejska, Barbara Dzida, Grzegorz Mosiewicz, Jerzy Medicina (Kaunas) Article Background and objectives: Diabetes mellitus represents a metabolic disorder the incidence of which has been on the increase in recent years. The well-known long-term complications of this disease encompass a wide spectrum of renal, neurological and cardiovascular conditions. The aim of the study was to investigate the serum concentration of endothelial microparticles (EMPs) as well as selected noninvasive parameters of the ascending aorta stiffness calculated with echocardiography. Materials and Methods: 58 patients were enrolled in this study—38 subjects diagnosed with type 2 diabetes mellitus (T2DM) and 20 healthy controls. The analyzed populations did not differ significantly with respect to age, renal function, systolic and diastolic blood pressure. Results: The patients with T2DM and concomitant hypertension presented higher levels of EMPs in comparison with diabetic normotensive subjects. Among patients with T2DM and hypertension, aortic stiffness assessed with the elasticity index (Ep) was higher and the aortic compliance index (D) lower than in the diabetic normotensive group. No correlation between the amount of EMPs and lipid profile, C-reactive protein (CRP) level and glycemia, was observed in the studied group. There was, however, a statistically significant positive correlation between the creatinine level and amount of EMPs, while the negative relationship was documented for EMPs level and the estimated glomerular filtration rate (eGFR). Conclusions: Considering the elevated number of EMPs in diabetic patients with hypertension as well as the positive correlation between EMPs and serum creatinine level, EMPs assessment could be useful in identifying patients who are at high risk of organ damage due to diabetes mellitus. MDPI 2019-09-16 /pmc/articles/PMC6780956/ /pubmed/31527473 http://dx.doi.org/10.3390/medicina55090596 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dec-Gilowska, Malgorzata
Trojnar, Marcin
Makaruk, Boguslaw
Czop, Marcin
Przybylska-Kuc, Sylwia
Mosiewicz-Madejska, Barbara
Dzida, Grzegorz
Mosiewicz, Jerzy
Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus
title Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus
title_full Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus
title_fullStr Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus
title_short Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus
title_sort circulating endothelial microparticles and aortic stiffness in patients with type 2 diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780956/
https://www.ncbi.nlm.nih.gov/pubmed/31527473
http://dx.doi.org/10.3390/medicina55090596
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