Risk of Zika microcephaly correlates with features of maternal antibodies

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2...

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Detalles Bibliográficos
Autores principales: Robbiani, Davide F., Olsen, Priscilla C., Costa, Federico, Wang, Qiao, Oliveira, Thiago Y., Nery, Nivison, Aromolaran, Adeolu, do Rosário, Mateus S., Sacramento, Gielson A., Cruz, Jaqueline S., Khouri, Ricardo, Wunder, Elsio A., Mattos, Adriana, de Paula Freitas, Bruno, Sarno, Manoel, Archanjo, Gracinda, Daltro, Dina, Carvalho, Gustavo B.S., Pimentel, Kleber, de Siqueira, Isadora C., de Almeida, João R.M., Henriques, Daniele F., Lima, Juliana A., Vasconcelos, Pedro F.C., Schaefer-Babajew, Dennis, Azzopardi, Stephanie A., Bozzacco, Leonia, Gazumyan, Anna, Belfort, Rubens, Alcântara, Ana P., Carvalho, Gustavo, Moreira, Licia, Araujo, Katiaci, Reis, Mitermayer G., Keesler, Rebekah I., Coffey, Lark L., Tisoncik-Go, Jennifer, Gale, Michael, Rajagopal, Lakshmi, Adams Waldorf, Kristina M., Dudley, Dawn M., Simmons, Heather A., Mejia, Andres, O’Connor, David H., Steinbach, Rosemary J., Haese, Nicole, Smith, Jessica, Lewis, Anne, Colgin, Lois, Roberts, Victoria, Frias, Antonio, Kelleher, Meredith, Hirsch, Alec, Streblow, Daniel N., Rice, Charles M., MacDonald, Margaret R., de Almeida, Antonio R.P., Van Rompay, Koen K.A., Ko, Albert I., Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781003/
https://www.ncbi.nlm.nih.gov/pubmed/31413072
http://dx.doi.org/10.1084/jem.20191061
Descripción
Sumario:Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.

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