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Risk of Zika microcephaly correlates with features of maternal antibodies

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2...

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Autores principales: Robbiani, Davide F., Olsen, Priscilla C., Costa, Federico, Wang, Qiao, Oliveira, Thiago Y., Nery, Nivison, Aromolaran, Adeolu, do Rosário, Mateus S., Sacramento, Gielson A., Cruz, Jaqueline S., Khouri, Ricardo, Wunder, Elsio A., Mattos, Adriana, de Paula Freitas, Bruno, Sarno, Manoel, Archanjo, Gracinda, Daltro, Dina, Carvalho, Gustavo B.S., Pimentel, Kleber, de Siqueira, Isadora C., de Almeida, João R.M., Henriques, Daniele F., Lima, Juliana A., Vasconcelos, Pedro F.C., Schaefer-Babajew, Dennis, Azzopardi, Stephanie A., Bozzacco, Leonia, Gazumyan, Anna, Belfort, Rubens, Alcântara, Ana P., Carvalho, Gustavo, Moreira, Licia, Araujo, Katiaci, Reis, Mitermayer G., Keesler, Rebekah I., Coffey, Lark L., Tisoncik-Go, Jennifer, Gale, Michael, Rajagopal, Lakshmi, Adams Waldorf, Kristina M., Dudley, Dawn M., Simmons, Heather A., Mejia, Andres, O’Connor, David H., Steinbach, Rosemary J., Haese, Nicole, Smith, Jessica, Lewis, Anne, Colgin, Lois, Roberts, Victoria, Frias, Antonio, Kelleher, Meredith, Hirsch, Alec, Streblow, Daniel N., Rice, Charles M., MacDonald, Margaret R., de Almeida, Antonio R.P., Van Rompay, Koen K.A., Ko, Albert I., Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781003/
https://www.ncbi.nlm.nih.gov/pubmed/31413072
http://dx.doi.org/10.1084/jem.20191061
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author Robbiani, Davide F.
Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Y.
Nery, Nivison
Aromolaran, Adeolu
do Rosário, Mateus S.
Sacramento, Gielson A.
Cruz, Jaqueline S.
Khouri, Ricardo
Wunder, Elsio A.
Mattos, Adriana
de Paula Freitas, Bruno
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B.S.
Pimentel, Kleber
de Siqueira, Isadora C.
de Almeida, João R.M.
Henriques, Daniele F.
Lima, Juliana A.
Vasconcelos, Pedro F.C.
Schaefer-Babajew, Dennis
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer G.
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Adams Waldorf, Kristina M.
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O’Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
de Almeida, Antonio R.P.
Van Rompay, Koen K.A.
Ko, Albert I.
Nussenzweig, Michel C.
author_facet Robbiani, Davide F.
Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Y.
Nery, Nivison
Aromolaran, Adeolu
do Rosário, Mateus S.
Sacramento, Gielson A.
Cruz, Jaqueline S.
Khouri, Ricardo
Wunder, Elsio A.
Mattos, Adriana
de Paula Freitas, Bruno
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B.S.
Pimentel, Kleber
de Siqueira, Isadora C.
de Almeida, João R.M.
Henriques, Daniele F.
Lima, Juliana A.
Vasconcelos, Pedro F.C.
Schaefer-Babajew, Dennis
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer G.
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Adams Waldorf, Kristina M.
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O’Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
de Almeida, Antonio R.P.
Van Rompay, Koen K.A.
Ko, Albert I.
Nussenzweig, Michel C.
author_sort Robbiani, Davide F.
collection PubMed
description Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
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spelling pubmed-67810032019-10-09 Risk of Zika microcephaly correlates with features of maternal antibodies Robbiani, Davide F. Olsen, Priscilla C. Costa, Federico Wang, Qiao Oliveira, Thiago Y. Nery, Nivison Aromolaran, Adeolu do Rosário, Mateus S. Sacramento, Gielson A. Cruz, Jaqueline S. Khouri, Ricardo Wunder, Elsio A. Mattos, Adriana de Paula Freitas, Bruno Sarno, Manoel Archanjo, Gracinda Daltro, Dina Carvalho, Gustavo B.S. Pimentel, Kleber de Siqueira, Isadora C. de Almeida, João R.M. Henriques, Daniele F. Lima, Juliana A. Vasconcelos, Pedro F.C. Schaefer-Babajew, Dennis Azzopardi, Stephanie A. Bozzacco, Leonia Gazumyan, Anna Belfort, Rubens Alcântara, Ana P. Carvalho, Gustavo Moreira, Licia Araujo, Katiaci Reis, Mitermayer G. Keesler, Rebekah I. Coffey, Lark L. Tisoncik-Go, Jennifer Gale, Michael Rajagopal, Lakshmi Adams Waldorf, Kristina M. Dudley, Dawn M. Simmons, Heather A. Mejia, Andres O’Connor, David H. Steinbach, Rosemary J. Haese, Nicole Smith, Jessica Lewis, Anne Colgin, Lois Roberts, Victoria Frias, Antonio Kelleher, Meredith Hirsch, Alec Streblow, Daniel N. Rice, Charles M. MacDonald, Margaret R. de Almeida, Antonio R.P. Van Rompay, Koen K.A. Ko, Albert I. Nussenzweig, Michel C. J Exp Med Research Articles Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly. Rockefeller University Press 2019-10-07 2019-08-14 /pmc/articles/PMC6781003/ /pubmed/31413072 http://dx.doi.org/10.1084/jem.20191061 Text en © 2019 Robbiani et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Articles
Robbiani, Davide F.
Olsen, Priscilla C.
Costa, Federico
Wang, Qiao
Oliveira, Thiago Y.
Nery, Nivison
Aromolaran, Adeolu
do Rosário, Mateus S.
Sacramento, Gielson A.
Cruz, Jaqueline S.
Khouri, Ricardo
Wunder, Elsio A.
Mattos, Adriana
de Paula Freitas, Bruno
Sarno, Manoel
Archanjo, Gracinda
Daltro, Dina
Carvalho, Gustavo B.S.
Pimentel, Kleber
de Siqueira, Isadora C.
de Almeida, João R.M.
Henriques, Daniele F.
Lima, Juliana A.
Vasconcelos, Pedro F.C.
Schaefer-Babajew, Dennis
Azzopardi, Stephanie A.
Bozzacco, Leonia
Gazumyan, Anna
Belfort, Rubens
Alcântara, Ana P.
Carvalho, Gustavo
Moreira, Licia
Araujo, Katiaci
Reis, Mitermayer G.
Keesler, Rebekah I.
Coffey, Lark L.
Tisoncik-Go, Jennifer
Gale, Michael
Rajagopal, Lakshmi
Adams Waldorf, Kristina M.
Dudley, Dawn M.
Simmons, Heather A.
Mejia, Andres
O’Connor, David H.
Steinbach, Rosemary J.
Haese, Nicole
Smith, Jessica
Lewis, Anne
Colgin, Lois
Roberts, Victoria
Frias, Antonio
Kelleher, Meredith
Hirsch, Alec
Streblow, Daniel N.
Rice, Charles M.
MacDonald, Margaret R.
de Almeida, Antonio R.P.
Van Rompay, Koen K.A.
Ko, Albert I.
Nussenzweig, Michel C.
Risk of Zika microcephaly correlates with features of maternal antibodies
title Risk of Zika microcephaly correlates with features of maternal antibodies
title_full Risk of Zika microcephaly correlates with features of maternal antibodies
title_fullStr Risk of Zika microcephaly correlates with features of maternal antibodies
title_full_unstemmed Risk of Zika microcephaly correlates with features of maternal antibodies
title_short Risk of Zika microcephaly correlates with features of maternal antibodies
title_sort risk of zika microcephaly correlates with features of maternal antibodies
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781003/
https://www.ncbi.nlm.nih.gov/pubmed/31413072
http://dx.doi.org/10.1084/jem.20191061
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