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Risk of Zika microcephaly correlates with features of maternal antibodies
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781003/ https://www.ncbi.nlm.nih.gov/pubmed/31413072 http://dx.doi.org/10.1084/jem.20191061 |
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author | Robbiani, Davide F. Olsen, Priscilla C. Costa, Federico Wang, Qiao Oliveira, Thiago Y. Nery, Nivison Aromolaran, Adeolu do Rosário, Mateus S. Sacramento, Gielson A. Cruz, Jaqueline S. Khouri, Ricardo Wunder, Elsio A. Mattos, Adriana de Paula Freitas, Bruno Sarno, Manoel Archanjo, Gracinda Daltro, Dina Carvalho, Gustavo B.S. Pimentel, Kleber de Siqueira, Isadora C. de Almeida, João R.M. Henriques, Daniele F. Lima, Juliana A. Vasconcelos, Pedro F.C. Schaefer-Babajew, Dennis Azzopardi, Stephanie A. Bozzacco, Leonia Gazumyan, Anna Belfort, Rubens Alcântara, Ana P. Carvalho, Gustavo Moreira, Licia Araujo, Katiaci Reis, Mitermayer G. Keesler, Rebekah I. Coffey, Lark L. Tisoncik-Go, Jennifer Gale, Michael Rajagopal, Lakshmi Adams Waldorf, Kristina M. Dudley, Dawn M. Simmons, Heather A. Mejia, Andres O’Connor, David H. Steinbach, Rosemary J. Haese, Nicole Smith, Jessica Lewis, Anne Colgin, Lois Roberts, Victoria Frias, Antonio Kelleher, Meredith Hirsch, Alec Streblow, Daniel N. Rice, Charles M. MacDonald, Margaret R. de Almeida, Antonio R.P. Van Rompay, Koen K.A. Ko, Albert I. Nussenzweig, Michel C. |
author_facet | Robbiani, Davide F. Olsen, Priscilla C. Costa, Federico Wang, Qiao Oliveira, Thiago Y. Nery, Nivison Aromolaran, Adeolu do Rosário, Mateus S. Sacramento, Gielson A. Cruz, Jaqueline S. Khouri, Ricardo Wunder, Elsio A. Mattos, Adriana de Paula Freitas, Bruno Sarno, Manoel Archanjo, Gracinda Daltro, Dina Carvalho, Gustavo B.S. Pimentel, Kleber de Siqueira, Isadora C. de Almeida, João R.M. Henriques, Daniele F. Lima, Juliana A. Vasconcelos, Pedro F.C. Schaefer-Babajew, Dennis Azzopardi, Stephanie A. Bozzacco, Leonia Gazumyan, Anna Belfort, Rubens Alcântara, Ana P. Carvalho, Gustavo Moreira, Licia Araujo, Katiaci Reis, Mitermayer G. Keesler, Rebekah I. Coffey, Lark L. Tisoncik-Go, Jennifer Gale, Michael Rajagopal, Lakshmi Adams Waldorf, Kristina M. Dudley, Dawn M. Simmons, Heather A. Mejia, Andres O’Connor, David H. Steinbach, Rosemary J. Haese, Nicole Smith, Jessica Lewis, Anne Colgin, Lois Roberts, Victoria Frias, Antonio Kelleher, Meredith Hirsch, Alec Streblow, Daniel N. Rice, Charles M. MacDonald, Margaret R. de Almeida, Antonio R.P. Van Rompay, Koen K.A. Ko, Albert I. Nussenzweig, Michel C. |
author_sort | Robbiani, Davide F. |
collection | PubMed |
description | Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly. |
format | Online Article Text |
id | pubmed-6781003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-67810032019-10-09 Risk of Zika microcephaly correlates with features of maternal antibodies Robbiani, Davide F. Olsen, Priscilla C. Costa, Federico Wang, Qiao Oliveira, Thiago Y. Nery, Nivison Aromolaran, Adeolu do Rosário, Mateus S. Sacramento, Gielson A. Cruz, Jaqueline S. Khouri, Ricardo Wunder, Elsio A. Mattos, Adriana de Paula Freitas, Bruno Sarno, Manoel Archanjo, Gracinda Daltro, Dina Carvalho, Gustavo B.S. Pimentel, Kleber de Siqueira, Isadora C. de Almeida, João R.M. Henriques, Daniele F. Lima, Juliana A. Vasconcelos, Pedro F.C. Schaefer-Babajew, Dennis Azzopardi, Stephanie A. Bozzacco, Leonia Gazumyan, Anna Belfort, Rubens Alcântara, Ana P. Carvalho, Gustavo Moreira, Licia Araujo, Katiaci Reis, Mitermayer G. Keesler, Rebekah I. Coffey, Lark L. Tisoncik-Go, Jennifer Gale, Michael Rajagopal, Lakshmi Adams Waldorf, Kristina M. Dudley, Dawn M. Simmons, Heather A. Mejia, Andres O’Connor, David H. Steinbach, Rosemary J. Haese, Nicole Smith, Jessica Lewis, Anne Colgin, Lois Roberts, Victoria Frias, Antonio Kelleher, Meredith Hirsch, Alec Streblow, Daniel N. Rice, Charles M. MacDonald, Margaret R. de Almeida, Antonio R.P. Van Rompay, Koen K.A. Ko, Albert I. Nussenzweig, Michel C. J Exp Med Research Articles Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly. Rockefeller University Press 2019-10-07 2019-08-14 /pmc/articles/PMC6781003/ /pubmed/31413072 http://dx.doi.org/10.1084/jem.20191061 Text en © 2019 Robbiani et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Articles Robbiani, Davide F. Olsen, Priscilla C. Costa, Federico Wang, Qiao Oliveira, Thiago Y. Nery, Nivison Aromolaran, Adeolu do Rosário, Mateus S. Sacramento, Gielson A. Cruz, Jaqueline S. Khouri, Ricardo Wunder, Elsio A. Mattos, Adriana de Paula Freitas, Bruno Sarno, Manoel Archanjo, Gracinda Daltro, Dina Carvalho, Gustavo B.S. Pimentel, Kleber de Siqueira, Isadora C. de Almeida, João R.M. Henriques, Daniele F. Lima, Juliana A. Vasconcelos, Pedro F.C. Schaefer-Babajew, Dennis Azzopardi, Stephanie A. Bozzacco, Leonia Gazumyan, Anna Belfort, Rubens Alcântara, Ana P. Carvalho, Gustavo Moreira, Licia Araujo, Katiaci Reis, Mitermayer G. Keesler, Rebekah I. Coffey, Lark L. Tisoncik-Go, Jennifer Gale, Michael Rajagopal, Lakshmi Adams Waldorf, Kristina M. Dudley, Dawn M. Simmons, Heather A. Mejia, Andres O’Connor, David H. Steinbach, Rosemary J. Haese, Nicole Smith, Jessica Lewis, Anne Colgin, Lois Roberts, Victoria Frias, Antonio Kelleher, Meredith Hirsch, Alec Streblow, Daniel N. Rice, Charles M. MacDonald, Margaret R. de Almeida, Antonio R.P. Van Rompay, Koen K.A. Ko, Albert I. Nussenzweig, Michel C. Risk of Zika microcephaly correlates with features of maternal antibodies |
title | Risk of Zika microcephaly correlates with features of maternal antibodies |
title_full | Risk of Zika microcephaly correlates with features of maternal antibodies |
title_fullStr | Risk of Zika microcephaly correlates with features of maternal antibodies |
title_full_unstemmed | Risk of Zika microcephaly correlates with features of maternal antibodies |
title_short | Risk of Zika microcephaly correlates with features of maternal antibodies |
title_sort | risk of zika microcephaly correlates with features of maternal antibodies |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781003/ https://www.ncbi.nlm.nih.gov/pubmed/31413072 http://dx.doi.org/10.1084/jem.20191061 |
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