Microglia: Same same, but different

Microglial identity in the central nervous system (CNS) is dependent on colony stimulating factor 1 receptor (CSF-1R) signaling and its ligands IL-34 and colony stimulating factor 1 (CSF-1). In this issue of JEM, Kana et al. (https://doi.org/10.1084/jem.20182037) make the important discovery that CS...

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Detalles Bibliográficos
Autores principales: Kierdorf, Katrin, Prinz, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781008/
https://www.ncbi.nlm.nih.gov/pubmed/31527071
http://dx.doi.org/10.1084/jem.20191535
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author Kierdorf, Katrin
Prinz, Marco
author_facet Kierdorf, Katrin
Prinz, Marco
author_sort Kierdorf, Katrin
collection PubMed
description Microglial identity in the central nervous system (CNS) is dependent on colony stimulating factor 1 receptor (CSF-1R) signaling and its ligands IL-34 and colony stimulating factor 1 (CSF-1). In this issue of JEM, Kana et al. (https://doi.org/10.1084/jem.20182037) make the important discovery that CSF-1, but not IL-34, orchestrates cerebellar microglial homeostasis in mice, and its deficiency resulted in severe cerebellar dysfunctions accompanied by defects in motor function and social behavior.
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spelling pubmed-67810082020-04-07 Microglia: Same same, but different Kierdorf, Katrin Prinz, Marco J Exp Med News Microglial identity in the central nervous system (CNS) is dependent on colony stimulating factor 1 receptor (CSF-1R) signaling and its ligands IL-34 and colony stimulating factor 1 (CSF-1). In this issue of JEM, Kana et al. (https://doi.org/10.1084/jem.20182037) make the important discovery that CSF-1, but not IL-34, orchestrates cerebellar microglial homeostasis in mice, and its deficiency resulted in severe cerebellar dysfunctions accompanied by defects in motor function and social behavior. Rockefeller University Press 2019-10-07 2019-09-16 /pmc/articles/PMC6781008/ /pubmed/31527071 http://dx.doi.org/10.1084/jem.20191535 Text en © 2019 Prinz and Kierdorf http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Kierdorf, Katrin
Prinz, Marco
Microglia: Same same, but different
title Microglia: Same same, but different
title_full Microglia: Same same, but different
title_fullStr Microglia: Same same, but different
title_full_unstemmed Microglia: Same same, but different
title_short Microglia: Same same, but different
title_sort microglia: same same, but different
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781008/
https://www.ncbi.nlm.nih.gov/pubmed/31527071
http://dx.doi.org/10.1084/jem.20191535
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