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A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer

In early gastric cancer (EGC), tumor invasion depth is an important factor for determining the treatment method. However, as endoscopic ultrasonography has limitations when measuring the exact depth in a clinical setting as endoscopists often depend on gross findings and personal experience. The pre...

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Autores principales: Yoon, Hong Jin, Kim, Seunghyup, Kim, Jie-Hyun, Keum, Ji-Soo, Oh, Sang-Il, Jo, Junik, Chun, Jaeyoung, Youn, Young Hoon, Park, Hyojin, Kwon, In Gyu, Choi, Seung Ho, Noh, Sung Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781189/
https://www.ncbi.nlm.nih.gov/pubmed/31454949
http://dx.doi.org/10.3390/jcm8091310
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author Yoon, Hong Jin
Kim, Seunghyup
Kim, Jie-Hyun
Keum, Ji-Soo
Oh, Sang-Il
Jo, Junik
Chun, Jaeyoung
Youn, Young Hoon
Park, Hyojin
Kwon, In Gyu
Choi, Seung Ho
Noh, Sung Hoon
author_facet Yoon, Hong Jin
Kim, Seunghyup
Kim, Jie-Hyun
Keum, Ji-Soo
Oh, Sang-Il
Jo, Junik
Chun, Jaeyoung
Youn, Young Hoon
Park, Hyojin
Kwon, In Gyu
Choi, Seung Ho
Noh, Sung Hoon
author_sort Yoon, Hong Jin
collection PubMed
description In early gastric cancer (EGC), tumor invasion depth is an important factor for determining the treatment method. However, as endoscopic ultrasonography has limitations when measuring the exact depth in a clinical setting as endoscopists often depend on gross findings and personal experience. The present study aimed to develop a model optimized for EGC detection and depth prediction, and we investigated factors affecting artificial intelligence (AI) diagnosis. We employed a visual geometry group(VGG)-16 model for the classification of endoscopic images as EGC (T1a or T1b) or non-EGC. To induce the model to activate EGC regions during training, we proposed a novel loss function that simultaneously measured classification and localization errors. We experimented with 11,539 endoscopic images (896 T1a-EGC, 809 T1b-EGC, and 9834 non-EGC). The areas under the curves of receiver operating characteristic curves for EGC detection and depth prediction were 0.981 and 0.851, respectively. Among the factors affecting AI prediction of tumor depth, only histologic differentiation was significantly associated, where undifferentiated-type histology exhibited a lower AI accuracy. Thus, the lesion-based model is an appropriate training method for AI in EGC. However, further improvements and validation are required, especially for undifferentiated-type histology.
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spelling pubmed-67811892019-10-30 A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer Yoon, Hong Jin Kim, Seunghyup Kim, Jie-Hyun Keum, Ji-Soo Oh, Sang-Il Jo, Junik Chun, Jaeyoung Youn, Young Hoon Park, Hyojin Kwon, In Gyu Choi, Seung Ho Noh, Sung Hoon J Clin Med Article In early gastric cancer (EGC), tumor invasion depth is an important factor for determining the treatment method. However, as endoscopic ultrasonography has limitations when measuring the exact depth in a clinical setting as endoscopists often depend on gross findings and personal experience. The present study aimed to develop a model optimized for EGC detection and depth prediction, and we investigated factors affecting artificial intelligence (AI) diagnosis. We employed a visual geometry group(VGG)-16 model for the classification of endoscopic images as EGC (T1a or T1b) or non-EGC. To induce the model to activate EGC regions during training, we proposed a novel loss function that simultaneously measured classification and localization errors. We experimented with 11,539 endoscopic images (896 T1a-EGC, 809 T1b-EGC, and 9834 non-EGC). The areas under the curves of receiver operating characteristic curves for EGC detection and depth prediction were 0.981 and 0.851, respectively. Among the factors affecting AI prediction of tumor depth, only histologic differentiation was significantly associated, where undifferentiated-type histology exhibited a lower AI accuracy. Thus, the lesion-based model is an appropriate training method for AI in EGC. However, further improvements and validation are required, especially for undifferentiated-type histology. MDPI 2019-08-26 /pmc/articles/PMC6781189/ /pubmed/31454949 http://dx.doi.org/10.3390/jcm8091310 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoon, Hong Jin
Kim, Seunghyup
Kim, Jie-Hyun
Keum, Ji-Soo
Oh, Sang-Il
Jo, Junik
Chun, Jaeyoung
Youn, Young Hoon
Park, Hyojin
Kwon, In Gyu
Choi, Seung Ho
Noh, Sung Hoon
A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer
title A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer
title_full A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer
title_fullStr A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer
title_full_unstemmed A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer
title_short A Lesion-Based Convolutional Neural Network Improves Endoscopic Detection and Depth Prediction of Early Gastric Cancer
title_sort lesion-based convolutional neural network improves endoscopic detection and depth prediction of early gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781189/
https://www.ncbi.nlm.nih.gov/pubmed/31454949
http://dx.doi.org/10.3390/jcm8091310
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