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An Update of Moisture Barrier Coating for Drug Delivery

Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from hy...

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Detalles Bibliográficos
Autores principales: Yang, Qingliang, Yuan, Feng, Xu, Lei, Yan, Qinying, Yang, Yan, Wu, Danjun, Guo, Fangyuan, Yang, Gensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781284/
https://www.ncbi.nlm.nih.gov/pubmed/31480542
http://dx.doi.org/10.3390/pharmaceutics11090436
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author Yang, Qingliang
Yuan, Feng
Xu, Lei
Yan, Qinying
Yang, Yan
Wu, Danjun
Guo, Fangyuan
Yang, Gensheng
author_facet Yang, Qingliang
Yuan, Feng
Xu, Lei
Yan, Qinying
Yang, Yan
Wu, Danjun
Guo, Fangyuan
Yang, Gensheng
author_sort Yang, Qingliang
collection PubMed
description Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from hydrolytic degradation during the manufacturing process and storage. Coating formulation design and process control are the two most commonly used strategies to reduce water vapor permeability to achieve the moisture barrier function. The principles of formulation development include designing a coating formulation with non-hygroscopic/low water activity excipients, and formulating the film-forming polymers with the least amount of inherent moisture. The coating process involves spraying organic or aqueous coating solutions made of natural or synthetic polymers onto the surface of the dosage cores in a drum or a fluid bed coater. However, the aqueous coating process needs to be carefully controlled to prevent hydrolytic degradation of the drug due to the presence of water during the coating process. Recently, different strategies have been designed and developed to effectively decrease water vapor permeability and improve the moisture barrier function of the film. Those strategies include newly designed coating formulations containing polymers with optimized functionality of moisture barrier, and newly developed dry coating processes that eliminate the usage of organic solvent and water, and could potentially replace the current solvent and aqueous coatings. This review aims to summarize the recent advances and updates in moisture barrier coatings.
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spelling pubmed-67812842019-10-30 An Update of Moisture Barrier Coating for Drug Delivery Yang, Qingliang Yuan, Feng Xu, Lei Yan, Qinying Yang, Yan Wu, Danjun Guo, Fangyuan Yang, Gensheng Pharmaceutics Review Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from hydrolytic degradation during the manufacturing process and storage. Coating formulation design and process control are the two most commonly used strategies to reduce water vapor permeability to achieve the moisture barrier function. The principles of formulation development include designing a coating formulation with non-hygroscopic/low water activity excipients, and formulating the film-forming polymers with the least amount of inherent moisture. The coating process involves spraying organic or aqueous coating solutions made of natural or synthetic polymers onto the surface of the dosage cores in a drum or a fluid bed coater. However, the aqueous coating process needs to be carefully controlled to prevent hydrolytic degradation of the drug due to the presence of water during the coating process. Recently, different strategies have been designed and developed to effectively decrease water vapor permeability and improve the moisture barrier function of the film. Those strategies include newly designed coating formulations containing polymers with optimized functionality of moisture barrier, and newly developed dry coating processes that eliminate the usage of organic solvent and water, and could potentially replace the current solvent and aqueous coatings. This review aims to summarize the recent advances and updates in moisture barrier coatings. MDPI 2019-09-01 /pmc/articles/PMC6781284/ /pubmed/31480542 http://dx.doi.org/10.3390/pharmaceutics11090436 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Qingliang
Yuan, Feng
Xu, Lei
Yan, Qinying
Yang, Yan
Wu, Danjun
Guo, Fangyuan
Yang, Gensheng
An Update of Moisture Barrier Coating for Drug Delivery
title An Update of Moisture Barrier Coating for Drug Delivery
title_full An Update of Moisture Barrier Coating for Drug Delivery
title_fullStr An Update of Moisture Barrier Coating for Drug Delivery
title_full_unstemmed An Update of Moisture Barrier Coating for Drug Delivery
title_short An Update of Moisture Barrier Coating for Drug Delivery
title_sort update of moisture barrier coating for drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781284/
https://www.ncbi.nlm.nih.gov/pubmed/31480542
http://dx.doi.org/10.3390/pharmaceutics11090436
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