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The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy

To date, our understanding of the Substance P (SP) and neurokinin 1 receptor (NK1R) system shows intricate relations between human physiology and disease occurrence or progression. Within the oncological field, overexpression of NK1R and this SP/NK1R system have been implicated in cancer cell progre...

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Autores principales: Majkowska-Pilip, Agnieszka, Halik, Paweł Krzysztof, Gniazdowska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781293/
https://www.ncbi.nlm.nih.gov/pubmed/31480582
http://dx.doi.org/10.3390/pharmaceutics11090443
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author Majkowska-Pilip, Agnieszka
Halik, Paweł Krzysztof
Gniazdowska, Ewa
author_facet Majkowska-Pilip, Agnieszka
Halik, Paweł Krzysztof
Gniazdowska, Ewa
author_sort Majkowska-Pilip, Agnieszka
collection PubMed
description To date, our understanding of the Substance P (SP) and neurokinin 1 receptor (NK1R) system shows intricate relations between human physiology and disease occurrence or progression. Within the oncological field, overexpression of NK1R and this SP/NK1R system have been implicated in cancer cell progression and poor overall prognosis. This review focuses on providing an update on the current state of knowledge around the wide spectrum of NK1R ligands and applications of radioligands as radiopharmaceuticals. In this review, data concerning both the chemical and biological aspects of peptide and nonpeptide ligands as agonists or antagonists in classical and nuclear medicine, are presented and discussed. However, the research presented here is primarily focused on NK1R nonpeptide antagonistic ligands and the potential application of SP/NK1R system in targeted radionuclide tumour therapy.
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spelling pubmed-67812932019-10-30 The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy Majkowska-Pilip, Agnieszka Halik, Paweł Krzysztof Gniazdowska, Ewa Pharmaceutics Review To date, our understanding of the Substance P (SP) and neurokinin 1 receptor (NK1R) system shows intricate relations between human physiology and disease occurrence or progression. Within the oncological field, overexpression of NK1R and this SP/NK1R system have been implicated in cancer cell progression and poor overall prognosis. This review focuses on providing an update on the current state of knowledge around the wide spectrum of NK1R ligands and applications of radioligands as radiopharmaceuticals. In this review, data concerning both the chemical and biological aspects of peptide and nonpeptide ligands as agonists or antagonists in classical and nuclear medicine, are presented and discussed. However, the research presented here is primarily focused on NK1R nonpeptide antagonistic ligands and the potential application of SP/NK1R system in targeted radionuclide tumour therapy. MDPI 2019-09-01 /pmc/articles/PMC6781293/ /pubmed/31480582 http://dx.doi.org/10.3390/pharmaceutics11090443 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Majkowska-Pilip, Agnieszka
Halik, Paweł Krzysztof
Gniazdowska, Ewa
The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
title The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
title_full The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
title_fullStr The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
title_full_unstemmed The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
title_short The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
title_sort significance of nk1 receptor ligands and their application in targeted radionuclide tumour therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781293/
https://www.ncbi.nlm.nih.gov/pubmed/31480582
http://dx.doi.org/10.3390/pharmaceutics11090443
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