Genome-wide allele-specific methylation is enriched at gene regulatory regions in a multi-generation pedigree from the Norfolk Island isolate

BACKGROUND: Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider importance in terms of gene regulation and disease risk. Here, we studied ASM by...

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Detalles Bibliográficos
Autores principales: Benton, Miles C., Lea, Rodney A., Macartney-Coxson, Donia, Sutherland, Heidi G., White, Nicole, Kennedy, Daniel, Mengersen, Kerry, Haupt, Larisa M., Griffiths, Lyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781349/
https://www.ncbi.nlm.nih.gov/pubmed/31594537
http://dx.doi.org/10.1186/s13072-019-0304-7

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