DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism

BACKGROUND: The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA methylation and cancer progression as a transcriptional repressor. The potential...

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Detalles Bibliográficos
Autores principales: Chen, Ling, Shi, Ying, Liu, Na, Wang, Zuli, Yang, Rui, Yan, Bin, Liu, Xiaoli, Lai, Weiwei, Liu, Yating, Xiao, Desheng, Zhou, Hu, Cheng, Yan, Cao, Ya, Liu, Shuang, Xia, Zanxian, Tao, Yongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781351/
https://www.ncbi.nlm.nih.gov/pubmed/31594538
http://dx.doi.org/10.1186/s13072-019-0302-9

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