Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair

While the aberrant translocation of the mixed-lineage leukemia (MLL) gene drives pathogenesis of acute myeloid leukemia (AML), it represents an independent predictor for poor prognosis of adult AML patients. Thus, small molecule inhibitors targeting menin-MLL fusion protein interaction have been eme...

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Detalles Bibliográficos
Autores principales: Ye, Jing, Zha, Jie, Shi, Yuanfei, Li, Yin, Yuan, Delin, Chen, Qinwei, Lin, Fusheng, Fang, Zhihong, Yu, Yong, Dai, Yun, Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781368/
https://www.ncbi.nlm.nih.gov/pubmed/31590682
http://dx.doi.org/10.1186/s13148-019-0723-0

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