Heterogeneous BCR-ABL1 signal patterns identified by fluorescence in situ hybridization are associated with leukemic clonal evolution and poorer prognosis in BCR-ABL1 positive leukemia

BACKGROUND: Although extensive use of tyrosine kinase inhibitors has resulted in high and durable response rate and prolonged survival time in patients with BCR-ABL1 positive chronic myeloid leukemia (CML) and acute leukemia, relapse and drug resistance still remain big challenges for clinicians. Mo...

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Detalles Bibliográficos
Autores principales: Zhang, Zhanglin, Chen, Zhiwei, Jiang, Mei, Liu, Shuyuan, Guo, Yang, Wan, Lagen, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781398/
https://www.ncbi.nlm.nih.gov/pubmed/31594548
http://dx.doi.org/10.1186/s12885-019-6137-8

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