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A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice
BACKGROUND: Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to be recognized by both DLL4 and JAG1 Notch ligands. We previously showed that a...
Autores principales: | Varshney, Shweta, Wei, Hua-Xing, Batista, Frank, Nauman, Mohd, Sundaram, Subha, Siminovitch, Katherine, Tanwar, Ankit, Stanley, Pamela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781419/ https://www.ncbi.nlm.nih.gov/pubmed/31590629 http://dx.doi.org/10.1186/s12861-019-0199-3 |
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