Kindlin-3 stokes the life span of podosomes

Macrophages and other cell types can form podosomes, highly dynamic adhesive structures that mediate the interaction of these cells with the surrounding matrix. In this issue, Klapproth et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201903109) find that kindlin-3 regulates podosome stabilit...

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Detalles Bibliográficos
Autor principal: Zhang, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781434/
https://www.ncbi.nlm.nih.gov/pubmed/31548283
http://dx.doi.org/10.1083/jcb.201909096
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author Zhang, Hongquan
author_facet Zhang, Hongquan
author_sort Zhang, Hongquan
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description Macrophages and other cell types can form podosomes, highly dynamic adhesive structures that mediate the interaction of these cells with the surrounding matrix. In this issue, Klapproth et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201903109) find that kindlin-3 regulates podosome stability by recruiting leupaxin, with concomitant effects on PTP-PEST phosphatase activity and paxillin phosphorylation.
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spelling pubmed-67814342020-04-07 Kindlin-3 stokes the life span of podosomes Zhang, Hongquan J Cell Biol Commentaries Macrophages and other cell types can form podosomes, highly dynamic adhesive structures that mediate the interaction of these cells with the surrounding matrix. In this issue, Klapproth et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201903109) find that kindlin-3 regulates podosome stability by recruiting leupaxin, with concomitant effects on PTP-PEST phosphatase activity and paxillin phosphorylation. Rockefeller University Press 2019-10-07 2019-09-23 /pmc/articles/PMC6781434/ /pubmed/31548283 http://dx.doi.org/10.1083/jcb.201909096 Text en © 2019 Zhang http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Zhang, Hongquan
Kindlin-3 stokes the life span of podosomes
title Kindlin-3 stokes the life span of podosomes
title_full Kindlin-3 stokes the life span of podosomes
title_fullStr Kindlin-3 stokes the life span of podosomes
title_full_unstemmed Kindlin-3 stokes the life span of podosomes
title_short Kindlin-3 stokes the life span of podosomes
title_sort kindlin-3 stokes the life span of podosomes
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781434/
https://www.ncbi.nlm.nih.gov/pubmed/31548283
http://dx.doi.org/10.1083/jcb.201909096
work_keys_str_mv AT zhanghongquan kindlin3stokesthelifespanofpodosomes

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