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Eph receptors and ephrins engage in cellular cannibalism
Eph receptors bind ephrins on neighboring cells, oligomerizing into adhesive complexes that recruit signaling molecules. Execution of their signature repulsive program then generates pulling forces, enabling a cell to engulf a piece of another cell. New mechanistic insights by Gong et al. (2019. J....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781436/ https://www.ncbi.nlm.nih.gov/pubmed/31537710 http://dx.doi.org/10.1083/jcb.201908074 |
Sumario: | Eph receptors bind ephrins on neighboring cells, oligomerizing into adhesive complexes that recruit signaling molecules. Execution of their signature repulsive program then generates pulling forces, enabling a cell to engulf a piece of another cell. New mechanistic insights by Gong et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201901032) define this process as a form of “cellular cannibalism.” |
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