The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica

A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimic...

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Autores principales: Ukwatta, Kushan M., Lawrence, Jennifer L., Wijayarathna, C. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781459/
https://www.ncbi.nlm.nih.gov/pubmed/31632831
http://dx.doi.org/10.1080/21501203.2019.1620892
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author Ukwatta, Kushan M.
Lawrence, Jennifer L.
Wijayarathna, C. D.
author_facet Ukwatta, Kushan M.
Lawrence, Jennifer L.
Wijayarathna, C. D.
author_sort Ukwatta, Kushan M.
collection PubMed
description A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit α-glucosidase. Nigronapthaphenyl showed antibacterial activities against Bacillus subtilis TISTR 088 and Bacillus cereus TISTR 688 with MIC values of 4 and 2 μg/mL respectively. Cytotoxicity against colon cancer cell line HCT 116 was found to be an IC(50) value of 9.62 ± 0.5 μM . This further showed potential anti-inflammatory activity amounting to an IC(50) of 6.2 ± 0.5 μM and also α-glucosidase inhibitory activity, with an IC(50) value of 6.9 ± 0.5 μM.
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spelling pubmed-67814592019-10-18 The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica Ukwatta, Kushan M. Lawrence, Jennifer L. Wijayarathna, C. D. Mycology Review A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit α-glucosidase. Nigronapthaphenyl showed antibacterial activities against Bacillus subtilis TISTR 088 and Bacillus cereus TISTR 688 with MIC values of 4 and 2 μg/mL respectively. Cytotoxicity against colon cancer cell line HCT 116 was found to be an IC(50) value of 9.62 ± 0.5 μM . This further showed potential anti-inflammatory activity amounting to an IC(50) of 6.2 ± 0.5 μM and also α-glucosidase inhibitory activity, with an IC(50) value of 6.9 ± 0.5 μM. Taylor & Francis 2019-05-24 /pmc/articles/PMC6781459/ /pubmed/31632831 http://dx.doi.org/10.1080/21501203.2019.1620892 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ukwatta, Kushan M.
Lawrence, Jennifer L.
Wijayarathna, C. D.
The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica
title The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica
title_full The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica
title_fullStr The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica
title_full_unstemmed The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica
title_short The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica
title_sort study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of nigronapthaphenyl, isolated from an extract of nigrospora sphaerica
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781459/
https://www.ncbi.nlm.nih.gov/pubmed/31632831
http://dx.doi.org/10.1080/21501203.2019.1620892
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