Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis

Enhanced carbonyl stress underlies a subset of schizophrenia, but its causal effects remain elusive. Here, we elucidated the molecular mechanism underlying the effects of carbonyl stress in iPS cells in which the gene encoding zinc metalloenzyme glyoxalase I (GLO1), a crucial enzyme for the clearanc...

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Detalles Bibliográficos
Autores principales: Toyoshima, Manabu, Jiang, Xuguang, Ogawa, Tadayuki, Ohnishi, Tetsuo, Yoshihara, Shogo, Balan, Shabeesh, Yoshikawa, Takeo, Hirokawa, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781483/
https://www.ncbi.nlm.nih.gov/pubmed/31591136
http://dx.doi.org/10.26508/lsa.201900478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781483/
https://www.ncbi.nlm.nih.gov/pubmed/31591136
http://dx.doi.org/10.26508/lsa.201900478

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