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Diagnostic and prognostic value of the BEX family in lung adenocarcinoma

Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated Th...

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Autores principales: Zhang, Zhong-Hao, Luan, Zhi-Yu, Han, Fei, Chen, Hong-Qiang, Liu, Wen-Bin, Liu, Jin-Yi, Cao, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781490/
https://www.ncbi.nlm.nih.gov/pubmed/31612060
http://dx.doi.org/10.3892/ol.2019.10905
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author Zhang, Zhong-Hao
Luan, Zhi-Yu
Han, Fei
Chen, Hong-Qiang
Liu, Wen-Bin
Liu, Jin-Yi
Cao, Jia
author_facet Zhang, Zhong-Hao
Luan, Zhi-Yu
Han, Fei
Chen, Hong-Qiang
Liu, Wen-Bin
Liu, Jin-Yi
Cao, Jia
author_sort Zhang, Zhong-Hao
collection PubMed
description Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atlas data and revealed that the BEX family was downregulated in LUAD tissues compared with adjacent non-cancerous tissues. Additionally, analysis of LUAD cohorts from the Oncomine database revealed similar results. Furthermore, the expression of BEX members was significantly decreased in several LUAD cell lines compared with normal lung epithelial cells in vitro. The aforementioned data mining and in vitro results suggested that the BEX family may be involved in the development of LUAD. Furthermore, receiver operating characteristic curve analysis revealed that BEX members exhibited high sensitivity and specificity for the diagnosis of patients with LUAD. The low expression levels of BEX1, BEX4 and BEX5 were associated with certain pathologic features, particularly in advanced LUAD. Survival analysis demonstrated that BEX members, particularly BEX4, were involved in the prognosis of patients with LUAD at early and late clinical stages. The results obtained in the current study suggested that BEX members may serve as potential tumor biomarkers for the diagnosis and prognosis of patients with LUAD.
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spelling pubmed-67814902019-10-14 Diagnostic and prognostic value of the BEX family in lung adenocarcinoma Zhang, Zhong-Hao Luan, Zhi-Yu Han, Fei Chen, Hong-Qiang Liu, Wen-Bin Liu, Jin-Yi Cao, Jia Oncol Lett Articles Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atlas data and revealed that the BEX family was downregulated in LUAD tissues compared with adjacent non-cancerous tissues. Additionally, analysis of LUAD cohorts from the Oncomine database revealed similar results. Furthermore, the expression of BEX members was significantly decreased in several LUAD cell lines compared with normal lung epithelial cells in vitro. The aforementioned data mining and in vitro results suggested that the BEX family may be involved in the development of LUAD. Furthermore, receiver operating characteristic curve analysis revealed that BEX members exhibited high sensitivity and specificity for the diagnosis of patients with LUAD. The low expression levels of BEX1, BEX4 and BEX5 were associated with certain pathologic features, particularly in advanced LUAD. Survival analysis demonstrated that BEX members, particularly BEX4, were involved in the prognosis of patients with LUAD at early and late clinical stages. The results obtained in the current study suggested that BEX members may serve as potential tumor biomarkers for the diagnosis and prognosis of patients with LUAD. D.A. Spandidos 2019-11 2019-09-20 /pmc/articles/PMC6781490/ /pubmed/31612060 http://dx.doi.org/10.3892/ol.2019.10905 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Zhong-Hao
Luan, Zhi-Yu
Han, Fei
Chen, Hong-Qiang
Liu, Wen-Bin
Liu, Jin-Yi
Cao, Jia
Diagnostic and prognostic value of the BEX family in lung adenocarcinoma
title Diagnostic and prognostic value of the BEX family in lung adenocarcinoma
title_full Diagnostic and prognostic value of the BEX family in lung adenocarcinoma
title_fullStr Diagnostic and prognostic value of the BEX family in lung adenocarcinoma
title_full_unstemmed Diagnostic and prognostic value of the BEX family in lung adenocarcinoma
title_short Diagnostic and prognostic value of the BEX family in lung adenocarcinoma
title_sort diagnostic and prognostic value of the bex family in lung adenocarcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781490/
https://www.ncbi.nlm.nih.gov/pubmed/31612060
http://dx.doi.org/10.3892/ol.2019.10905
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