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Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma

The present study aimed to evaluate the hepatic hemodynamics of patients with α-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) and early recurrence (ER), as determined by color Doppler ultrasound. Screening with color Doppler ultrasound was performed in 150 patients with AFP-positive HCC,...

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Autores principales: Chen, Miao, Wang, Duo, Zhao, Yuan, Lu, Dan-Mei, Li, Hong-Xue, Liu, Jun-Jie, Li, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781491/
https://www.ncbi.nlm.nih.gov/pubmed/31611979
http://dx.doi.org/10.3892/ol.2019.10825
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author Chen, Miao
Wang, Duo
Zhao, Yuan
Lu, Dan-Mei
Li, Hong-Xue
Liu, Jun-Jie
Li, Hang
author_facet Chen, Miao
Wang, Duo
Zhao, Yuan
Lu, Dan-Mei
Li, Hong-Xue
Liu, Jun-Jie
Li, Hang
author_sort Chen, Miao
collection PubMed
description The present study aimed to evaluate the hepatic hemodynamics of patients with α-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) and early recurrence (ER), as determined by color Doppler ultrasound. Screening with color Doppler ultrasound was performed in 150 patients with AFP-positive HCC, yielding 43 cases with postoperative ER. In addition, 35 healthy controls were enrolled in the study for comparison of the blood flow parameters between the healthy control and the HCC groups. Receiver operating characteristic curve analysis was performed to evaluate the predicted effect of Doppler for the ER of HCC. The average mean flow velocity of portal vein in patients with HCC (14.686±5.873 cm/s) was significantly lower in the HCC group compared with the healthy control group (17.631±3.569 cm/s; P=0.005). Additionally, the preoperative portal vein diameter in the HCC group was significantly higher compared with that in the healthy control group (P=0.001). Regarding the effect of surgery, the portal vein diameter was significantly increased in the patients postoperatively compared with preoperatively (P=0.003), while the pulsation and resistance indexes exhibited a decreasing trend in the postoperative group (P=0.001 and P=0.003, respectively). Notably, patients with HCC and ER presented with a higher resistance index (1.163±0.342) compared with the ER-free group (1.023±0.176; P=0.004). Furthermore, a significant difference in hepatic artery pulsation index was also observed between the ER group (0.673±0.075) and the ER-free group (0.624±0.056; P=0.018), indicating that an increased hepatic artery pulsation index may significantly predict the ER of HCC. In addition, areas under the curve of 0.683 and 0.700, respectively, suggested that the hepatic artery resistance and pulsation indexes may be used to diagnose ER in HCC (P=0.009 and P=0.004, respectively). Taken together, Doppler ultrasound provides a reliable and accurate quantification of hepatic hemodynamics for detecting ER in HCC with a good diagnostic accuracy.
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spelling pubmed-67814912019-10-14 Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma Chen, Miao Wang, Duo Zhao, Yuan Lu, Dan-Mei Li, Hong-Xue Liu, Jun-Jie Li, Hang Oncol Lett Articles The present study aimed to evaluate the hepatic hemodynamics of patients with α-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) and early recurrence (ER), as determined by color Doppler ultrasound. Screening with color Doppler ultrasound was performed in 150 patients with AFP-positive HCC, yielding 43 cases with postoperative ER. In addition, 35 healthy controls were enrolled in the study for comparison of the blood flow parameters between the healthy control and the HCC groups. Receiver operating characteristic curve analysis was performed to evaluate the predicted effect of Doppler for the ER of HCC. The average mean flow velocity of portal vein in patients with HCC (14.686±5.873 cm/s) was significantly lower in the HCC group compared with the healthy control group (17.631±3.569 cm/s; P=0.005). Additionally, the preoperative portal vein diameter in the HCC group was significantly higher compared with that in the healthy control group (P=0.001). Regarding the effect of surgery, the portal vein diameter was significantly increased in the patients postoperatively compared with preoperatively (P=0.003), while the pulsation and resistance indexes exhibited a decreasing trend in the postoperative group (P=0.001 and P=0.003, respectively). Notably, patients with HCC and ER presented with a higher resistance index (1.163±0.342) compared with the ER-free group (1.023±0.176; P=0.004). Furthermore, a significant difference in hepatic artery pulsation index was also observed between the ER group (0.673±0.075) and the ER-free group (0.624±0.056; P=0.018), indicating that an increased hepatic artery pulsation index may significantly predict the ER of HCC. In addition, areas under the curve of 0.683 and 0.700, respectively, suggested that the hepatic artery resistance and pulsation indexes may be used to diagnose ER in HCC (P=0.009 and P=0.004, respectively). Taken together, Doppler ultrasound provides a reliable and accurate quantification of hepatic hemodynamics for detecting ER in HCC with a good diagnostic accuracy. D.A. Spandidos 2019-11 2019-09-09 /pmc/articles/PMC6781491/ /pubmed/31611979 http://dx.doi.org/10.3892/ol.2019.10825 Text en Copyright: © Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Chen, Miao
Wang, Duo
Zhao, Yuan
Lu, Dan-Mei
Li, Hong-Xue
Liu, Jun-Jie
Li, Hang
Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma
title Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma
title_full Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma
title_fullStr Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma
title_full_unstemmed Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma
title_short Preoperative color Doppler ultrasonography predicts early recurrence in AFP-positive hepatocellular carcinoma
title_sort preoperative color doppler ultrasonography predicts early recurrence in afp-positive hepatocellular carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781491/
https://www.ncbi.nlm.nih.gov/pubmed/31611979
http://dx.doi.org/10.3892/ol.2019.10825
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