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Evaluation of Tobramycin and Ciprofloxacin as a Synergistic Combination Against Hypermutable Pseudomonas Aeruginosa Strains via Mechanism-Based Modelling

Hypermutable Pseudomonas aeruginosa strains have a greatly increased mutation rate and are prevalent in chronic respiratory infections. Initially, we systematically evaluated the time-course of total and resistant populations of hypermutable (PAO∆mutS) and non-hypermutable (PAO1) P. aeruginosa strai...

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Detalles Bibliográficos
Autores principales:	Rees, Vanessa E., Bulitta, Jürgen B., Oliver, Antonio, Nation, Roger L., Landersdorfer, Cornelia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781503/ https://www.ncbi.nlm.nih.gov/pubmed/31547301 http://dx.doi.org/10.3390/pharmaceutics11090470

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