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Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles

We previously reported that siRNA delivery to the brain is improved by the nose-to-brain delivery route and by conjugation with polyethylene glycol-polycaprolactone (PEG-PCL) polymer micelles and the cell-penetrating peptide, Tat (PEG-PCL-Tat). In this study, we evaluated the nose-to-brain delivery...

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Detalles Bibliográficos
Autores principales:	Kanazawa, Takanori, Kurano, Takumi, Ibaraki, Hisako, Takashima, Yuuki, Suzuki, Toyofumi, Seta, Yasuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781507/ https://www.ncbi.nlm.nih.gov/pubmed/31540164 http://dx.doi.org/10.3390/pharmaceutics11090478

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