Anticancer effect of XAV939 is observed by inhibiting lactose dehydrogenase A in a 3-dimensional culture of colorectal cancer cells

XAV939, a tankyrase inhibitor, exerts an anticancer effect in 3-dimensional (3D) cultured SW480 cells, however this is not exhibited in 2-dimensional (2D) cultured SW480 cells. In the current study, XAV939 induced a 3.7-fold increase in cellular apoptosis in 3D culture but not in the 2D culture. How...

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Detalles Bibliográficos
Autores principales: Kim, Dahee, Koh, Byumseok, Kim, Kwang Rok, Kim, Ki Young, Jung, Won Hoon, Kim, Hi Youn, Kim, Sungsub, Dal Rhee, Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781734/
https://www.ncbi.nlm.nih.gov/pubmed/31611996
http://dx.doi.org/10.3892/ol.2019.10813

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