LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11

PURPOSE: The oncogenic roles of lncRNA LINC01116 have been reported in several types of cancer, while its involvement in gastric cancer is unknown. This study aimed to investigate the involvement of LINC01116 in gastric cancer. METHODS: Gene expression was detected by qPCR. Correlations were analyze...

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Autores principales: Su, Xiaohui, Zhang, Jianjun, Luo, Xianfeng, Yang, Wei, Liu, Yanqing, Liu, Yang, Shan, Zexing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781852/
https://www.ncbi.nlm.nih.gov/pubmed/31632064
http://dx.doi.org/10.2147/OTT.S208133
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author Su, Xiaohui
Zhang, Jianjun
Luo, Xianfeng
Yang, Wei
Liu, Yanqing
Liu, Yang
Shan, Zexing
author_facet Su, Xiaohui
Zhang, Jianjun
Luo, Xianfeng
Yang, Wei
Liu, Yanqing
Liu, Yang
Shan, Zexing
author_sort Su, Xiaohui
collection PubMed
description PURPOSE: The oncogenic roles of lncRNA LINC01116 have been reported in several types of cancer, while its involvement in gastric cancer is unknown. This study aimed to investigate the involvement of LINC01116 in gastric cancer. METHODS: Gene expression was detected by qPCR. Correlations were analyzed by linear regression. Overexpression and siRNA silencing techniques were used to analyze gene functions. Cell invasion and migration were analyzed by Transwell assays. RESULTS: LINC01116 and lncRNA CASC11 were both upregulated in cancer tissues compared to cancer-adjacent tissues. Expression levels of LINC01116 and CASC11 were increased with the increase in clinical stages. Expression levels of LINC01116 and CASC11 were positively correlated. Overexpression of LINC01116 mediated the upregulated CASC11 in gastric cancer cells, and CASC11 overexpression also led to overexpressed LINC01116. Overexpression of LINC01116 and CASC11 led to promoted invasion and migration of gastric cancer cells. Rescue experiments showed that CASC11 knockdown attenuated the effects of LINC01116 overexpression. Overexpression of LINC01116 failed to significantly affect cancer cell proliferation. CONCLUSION: LINC01116 promoted cancer cell invasion and migration in gastric cancer by positively interacting with CASC11.
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spelling pubmed-67818522019-10-18 LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11 Su, Xiaohui Zhang, Jianjun Luo, Xianfeng Yang, Wei Liu, Yanqing Liu, Yang Shan, Zexing Onco Targets Ther Original Research PURPOSE: The oncogenic roles of lncRNA LINC01116 have been reported in several types of cancer, while its involvement in gastric cancer is unknown. This study aimed to investigate the involvement of LINC01116 in gastric cancer. METHODS: Gene expression was detected by qPCR. Correlations were analyzed by linear regression. Overexpression and siRNA silencing techniques were used to analyze gene functions. Cell invasion and migration were analyzed by Transwell assays. RESULTS: LINC01116 and lncRNA CASC11 were both upregulated in cancer tissues compared to cancer-adjacent tissues. Expression levels of LINC01116 and CASC11 were increased with the increase in clinical stages. Expression levels of LINC01116 and CASC11 were positively correlated. Overexpression of LINC01116 mediated the upregulated CASC11 in gastric cancer cells, and CASC11 overexpression also led to overexpressed LINC01116. Overexpression of LINC01116 and CASC11 led to promoted invasion and migration of gastric cancer cells. Rescue experiments showed that CASC11 knockdown attenuated the effects of LINC01116 overexpression. Overexpression of LINC01116 failed to significantly affect cancer cell proliferation. CONCLUSION: LINC01116 promoted cancer cell invasion and migration in gastric cancer by positively interacting with CASC11. Dove 2019-10-03 /pmc/articles/PMC6781852/ /pubmed/31632064 http://dx.doi.org/10.2147/OTT.S208133 Text en © 2019 Su et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Su, Xiaohui
Zhang, Jianjun
Luo, Xianfeng
Yang, Wei
Liu, Yanqing
Liu, Yang
Shan, Zexing
LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11
title LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11
title_full LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11
title_fullStr LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11
title_full_unstemmed LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11
title_short LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11
title_sort lncrna linc01116 promotes cancer cell proliferation, migration and invasion in gastric cancer by positively interacting with lncrna casc11
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781852/
https://www.ncbi.nlm.nih.gov/pubmed/31632064
http://dx.doi.org/10.2147/OTT.S208133
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