Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

Knockdown or gene disruption of the ubiquitously expressed cell surface receptor CD47 protects non-malignant cells from genotoxic stress caused by ionizing radiation or cytotoxic chemotherapy but sensitizes tumors in an immune competent host to genotoxic stress. The selective radioprotection of non-...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaur, Sukhbir, Schwartz, Anthony L., Jordan, David G., Soto-Pantoja, David R., Kuo, Bethany, Elkahloun, Abdel G., Mathews Griner, Lesley, Thomas, Craig J., Ferrer, Marc, Thomas, Anish, Tang, Sai-Wen, Rajapakse, Vinodh N., Pommier, Yves, Roberts, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781860/
https://www.ncbi.nlm.nih.gov/pubmed/31632920
http://dx.doi.org/10.3389/fonc.2019.00994

Ejemplares similares

Ejemplares similares