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Circulating glucuronic acid predicts healthspan and longevity in humans and mice
Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We fi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781977/ https://www.ncbi.nlm.nih.gov/pubmed/31557729 http://dx.doi.org/10.18632/aging.102281 |
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author | Ho, Andrew Sinick, Jonah Esko, Tõnu Fischer, Krista Menni, Cristina Zierer, Jonas Matey-Hernandez, Maria Fortney, Kristen Morgen, Eric K. |
author_facet | Ho, Andrew Sinick, Jonah Esko, Tõnu Fischer, Krista Menni, Cristina Zierer, Jonas Matey-Hernandez, Maria Fortney, Kristen Morgen, Eric K. |
author_sort | Ho, Andrew |
collection | PubMed |
description | Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10(-6) in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan. |
format | Online Article Text |
id | pubmed-6781977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-67819772019-10-16 Circulating glucuronic acid predicts healthspan and longevity in humans and mice Ho, Andrew Sinick, Jonah Esko, Tõnu Fischer, Krista Menni, Cristina Zierer, Jonas Matey-Hernandez, Maria Fortney, Kristen Morgen, Eric K. Aging (Albany NY) Research Paper Glucuronic acid is a metabolite of glucose that is involved in the detoxification of xenobiotic compounds and the structure/remodeling of the extracellular matrix. We report for the first time that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species. We find that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries with 4-20 years of follow-up (HR=1.44, p=2.9×10(-6) in the discovery cohort; HR=1.13, p=0.032 and HR=1.25, p=0.017, respectively in the replication cohorts), as well as in a longitudinal study of genetically heterogenous mice (HR=1.29, p=0.018). Additionally, we find that glucuronic acid levels increase with age and predict future healthspan-related outcomes. Together, these results demonstrate glucuronic acid as a robust biomarker of longevity and healthspan. Impact Journals 2019-09-26 /pmc/articles/PMC6781977/ /pubmed/31557729 http://dx.doi.org/10.18632/aging.102281 Text en Copyright © 2019 Ho et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ho, Andrew Sinick, Jonah Esko, Tõnu Fischer, Krista Menni, Cristina Zierer, Jonas Matey-Hernandez, Maria Fortney, Kristen Morgen, Eric K. Circulating glucuronic acid predicts healthspan and longevity in humans and mice |
title | Circulating glucuronic acid predicts healthspan and longevity in humans and mice |
title_full | Circulating glucuronic acid predicts healthspan and longevity in humans and mice |
title_fullStr | Circulating glucuronic acid predicts healthspan and longevity in humans and mice |
title_full_unstemmed | Circulating glucuronic acid predicts healthspan and longevity in humans and mice |
title_short | Circulating glucuronic acid predicts healthspan and longevity in humans and mice |
title_sort | circulating glucuronic acid predicts healthspan and longevity in humans and mice |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781977/ https://www.ncbi.nlm.nih.gov/pubmed/31557729 http://dx.doi.org/10.18632/aging.102281 |
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