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MiR-27a promotes insulin resistance and mediates glucose metabolism by targeting PPAR-γ-mediated PI3K/AKT signaling
This study aimed to establish a high-fat diet (HFD)-fed obese mouse model and a cell culture model of insulin resistance (IR) in mature 3T3-L1 adipocytes. A dual-luciferase reporter assay (DLRA) was confirmed interaction between miR-27a and the 3′-untranslated region (UTR) of Peroxisome proliferator...
Autores principales: | Chen, Tianbao, Zhang, Yi, Liu, Yilan, Zhu, Dexiao, Yu, Jing, Li, Guoqian, Sun, Zhichun, Wang, Wanru, Jiang, Hongwei, Hong, Zhenzhen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781997/ https://www.ncbi.nlm.nih.gov/pubmed/31562809 http://dx.doi.org/10.18632/aging.102263 |
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